Senior Structural Biology Protein Biochemist

Placements24; Pretoria; Hybrid; ZAR 900,000 - 1,300,000; Full time

Benefits offered by this job

Health insurance

Retirement plan

Professional development opportunities

Relocation assistance

Job summary

Placements24 is seeking a Senior Protein Biochemist with expertise in structural biology for a leading biotechnology firm in Pretoria. You will lead expression, purification, and characterization of therapeutic proteins, focusing on structure determination by X-ray crystallography or Cryo-EM within a dynamic R&D team.

The role requires a PhD and at least five years in protein biochemistry and structural biology, with experience in recombinant expression in multiple systems and biophysical

Qualifications

• Ph.D. in Biochemistry, Biophysics, Structural Biology, or related field.
• Minimum 5 years post-doctoral or industry experience in protein biochemistry and structural biology.
• Proven expertise in recombinant protein expression and purification techniques.
• Experience with structure determination using X-ray crystallography or Cryo-EM.
• Experience with biophysical characterization techniques such as SPR, ITC, CD, DSC, and mass spectrometry.

Responsibilities

• Design and execute recombinant expression and purification of challenging protein targets.
• Characterize protein structure, function, and stability using biophysical methods.
• Lead efforts in obtaining high-resolution structural data via X-ray or Cryo-EM.
• Analyze and interpret structural data and integrate with other results.
• Collaborate with molecular biologists, medicinal chemists, and computational scientists on drug discovery.
• Develop and optimize production and purification protocols for various applications.
• Troubleshoot experimental challenges and propose solutions.
• Mentor junior scientists and contribute to scientific direction.

Skills

Analytical mindset

Communication skills

Team leadership

Education

PhD in Biochemistry / Biophysics / Structural Biology

Tools

X-ray crystallography

Cryo-EM

SPR

ITC

Mass spectrometry

Job description

Placements24 is seeking a Senior Protein Biochemist with expertise in structural biology for a leading biotechnology firm in Pretoria. You will lead expression, purification, and characterization of therapeutic proteins, focusing on structure determination by X-ray crystallography or Cryo-EM within a dynamic R&D team.

The role requires a PhD and at least five years in protein biochemistry and structural biology, with experience in recombinant expression in multiple systems and biophysical