Senior Structural Chemist – Drug Discovery & Crystallography

Placements24; Stellenbosch; Vor Ort; ZAR 1.000.000 - 1.400.000; Vollzeit

Benefits dieser Stelle

Medical aid

Provident fund

Performance-based bonuses

Professional development

Zusammenfassung

Placements24 is seeking a Senior Structural Chemist to join a leading pharmaceutical research team in Paarl, Western Cape. The role focuses on determining 3D structures of small molecules and biomolecules using X-ray crystallography and NMR, supporting drug design and discovery efforts.

The successful candidate will collaborate with medicinal chemistry, biology, and computational modelers, operate advanced instrumentation, and contribute to developing new structural biology methodologies and

Qualifikationen

• Ph.D. in Chemistry, Biochemistry, Structural Biology or related field.
• Minimum 5 years postdoc/industrial experience in X-ray crystallography and/or NMR spectroscopy.
• Proven track record solving crystal structures of small molecules and/or proteins.
• Experience with crystallization screening and optimization.
• Proficiency with crystallographic software packages (Phenix, CCP4, SHELX).
• Experience with NMR data acquisition/analysis (TOPSPIN, NMRPipe).
• Strong understanding of molecular biology and medicinal chemistry.
• Excellent analytical and problem-solving skills.
• Effective written and verbal communication.

Aufgaben

• Perform X-ray crystallography studies to determine 3D structures of small molecules and protein-ligand complexes.
• Utilize NMR spectroscopy for structural characterization and conformational analysis.
• Collaborate with computational chemists to interpret data and guide drug design.
• Optimize crystallization conditions for challenging targets.
• Operate and maintain diffraction instrumentation and software.
• Interpret crystallographic and spectroscopic data to derive structure.

Kenntnisse

X-ray crystallography

NMR spectroscopy

Structural biology

Data analysis

Scientific communication

Ausbildung

Ph.D. in Chemistry, Biochemistry, or Structural Biology

Tools

Phenix

CCP4

SHELX

TOPSPIN

NMRPipe

Jobbeschreibung

Placements24 is seeking a Senior Structural Chemist to join a leading pharmaceutical research team in Paarl, Western Cape. The role focuses on determining 3D structures of small molecules and biomolecules using X-ray crystallography and NMR, supporting drug design and discovery efforts.

The successful candidate will collaborate with medicinal chemistry, biology, and computational modelers, operate advanced instrumentation, and contribute to developing new structural biology methodologies and