Senior Protein Biochemist – Therapeutics & Biophysics

Placements24; East London; Hybrid; ZAR 1.000.000 - 1.400.000; Vollzeit

Benefits dieser Stelle

Health insurance

Retirement plan

Career development opportunities

Zusammenfassung

Placements24 in East London, Eastern Cape is seeking a Senior Protein Biochemist to lead purification, characterization, and functional assessment of therapeutic proteins in a dynamic R&D team.

You will use chromatography, biophysical tools, and activity assays to advance protein programs, interpret data, and contribute to reports and regulatory documents.

The role emphasizes collaboration across biology, formulation, and development teams in a cutting-edge biotherapeutics environment.

Qualifikationen

• Ph.D. in Biochemistry, Biophysics, Molecular Biology, or related field.
• Minimum of 5 years of hands-on experience in protein biochemistry and purification.
• Proven expertise in protein expression (e.g., E. coli, mammalian cells), purification, and characterization.
• Strong experience with biophysical techniques such as UV-Vis spectroscopy, fluorescence spectroscopy, CD spectroscopy, DSC, and ITC.
• Proficiency in enzyme kinetics and protein-protein interaction analysis.
• Experience with various chromatographic methods is essential.
• Excellent analytical, problem-solving, and organizational skills.
• Strong communication and interpersonal skills, with the ability to work effectively in a team.
• Experience with therapeutic protein development is a plus.

Aufgaben

• Perform purification and characterization of recombinant proteins using various chromatographic techniques (e.g., affinity, ion-exchange, size-exclusion).
• Conduct comprehensive biophysical and biochemical analyses to assess protein structure, stability, and function.
• Characterize enzyme kinetics and binding interactions of therapeutic proteins.
• Develop and optimize assays for protein activity and quality control.
• Troubleshoot protein expression and purification challenges.
• Collaborate with molecular biologists, cell biologists, and formulation scientists to advance protein therapeutic programs.
• Analyze and interpret experimental data, presenting findings to project teams and senior management.
• Stay abreast of the latest advancements in protein biochemistry and biophysical characterization methods.
• Contribute to the preparation of technical reports, manuscripts, and regulatory documentation.

Kenntnisse

Protein biochemistry

Protein purification

Protein expression

Enzyme kinetics

Biophysical characterization

Chromatography

UV-Vis spectroscopy

Fluorescence spectroscopy

CD spectroscopy

DSC

ITC

Analytical problem solving

Communication skills

Ausbildung

Ph.D. in Biochemistry, Biophysics, Molecular Biology, or related field

Tools

Chromatography

UV-Vis spectroscopy

Fluorescence spectroscopy

CD spectroscopy

DSC

ITC

Jobbeschreibung

Placements24 in East London, Eastern Cape is seeking a Senior Protein Biochemist to lead purification, characterization, and functional assessment of therapeutic proteins in a dynamic R&D team.

You will use chromatography, biophysical tools, and activity assays to advance protein programs, interpret data, and contribute to reports and regulatory documents.

The role emphasizes collaboration across biology, formulation, and development teams in a cutting-edge biotherapeutics environment.