Senior Process Development Chemist

Placements24; LegKraal Gate; In loco; ZAR 1.200.000 - 1.800.000; Tempo pieno

Vantaggi offerti da questo lavoro

Competitive salary

Performance incentives

Health benefits

Retirement savings plan

Professional development

Conference attendance

Descrizione del lavoro

PLACEMENTS24 in Mahikeng, North West, is seeking a Senior Process Development Chemist to lead scale-up of chemical synthesis processes from lab to full production, ensuring safety and regulatory compliance.

You will collaborate with R&D, engineering, and production to translate discoveries into robust manufacturing, optimize kinetics and mass transfer, and mentor junior chemists and engineers in process development.

Competenze

• MSc or PhD in Organic Chemistry, Chemical Engineering, or related field.
• Minimum 6 years in process chemistry or chemical process development.
• Expertise in optimization, scale-up and technology transfer.
• Strong understanding of reaction mechanisms, kinetics, and thermodynamics.
• Knowledge of process safety principles and hazard analysis (HAZOP).
• Experience with unit operations: reaction, distillation, filtration, drying.
• DoE and process modeling is highly desirable.
• Excellent problem-solving and hands-on development approach.
• Strong written and verbal communication; cgMP experience is a plus.

Mansioni

• Lead development and optimization of synthesis processes for scale-up.
• Design experiments to evaluate kinetics, thermodynamics, and mass transfer.
• Identify and mitigate process safety hazards and ensure compliance.
• Develop process control strategies for efficient manufacturing.
• Troubleshoot deviations and implement corrective actions.
• Collaborate with engineering to design and commission new equipment.
• Prepare batch records and standard operating procedures.
• Conduct techno-economic assessments of new processes.
• Mentor junior chemists and engineers in development activities.

Conoscenze

Process optimization

Scale-up

DoE

Process modeling

Kinetics & thermodynamics

Problem solving

Communication

Formazione

MSc or PhD in Organic Chemistry / Chemical Engineering

Descrizione del lavoro

About the Role

Our client, a dynamic chemical manufacturing company, is seeking an experienced Senior Process Development Chemist to join their innovation hub in Mahikeng, North West, ZA. This role is pivotal in optimizing and scaling up chemical synthesis processes for the efficient and safe production of new chemical entities. You will work closely with R&D, engineering, and production teams to translate laboratory-scale discoveries into robust, large-scale manufacturing processes. The ideal candidate will possess a strong background in organic chemistry, chemical engineering principles, and process optimization, with extensive experience in process safety and scale-up. This is an excellent opportunity to contribute to the advancement of chemical manufacturing technologies and drive product development from concept to commercialization. Your expertise will be crucial in ensuring efficient and sustainable chemical production.

Key Responsibilities

• Lead the development and optimization of chemical synthesis processes for scale-up.
• Design and conduct experiments to evaluate reaction kinetics, thermodynamics, and mass transfer.
• Identify and mitigate process safety hazards, ensuring compliance with all safety regulations.
• Develop process control strategies and parameters for efficient and reproducible manufacturing.
• Troubleshoot process deviations and implement corrective actions.
• Collaborate with engineering teams to design and commission new process equipment.
• Prepare detailed process documentation, including batch records and standard operating procedures.
• Conduct techno-economic assessments of new processes.
• Mentor junior chemists and engineers involved in process development activities.
• Stay current with advancements in process chemistry and chemical engineering.

Requirements

• M.Sc. or Ph.D. in Organic Chemistry, Chemical Engineering, or a related field.
• Minimum of 6 years of experience in process chemistry or chemical process development within the chemical or pharmaceutical industry.
• Proven expertise in process optimization, scale-up, and technology transfer.
• Strong understanding of reaction mechanisms, kinetics, and thermodynamics.
• Demonstrated knowledge of process safety principles and hazard analysis (e.g., HAZOP).
• Experience with various unit operations (e.g., reaction, distillation, filtration, drying).
• Proficiency in statistical experimental design (DoE) and process modeling is highly desirable.
• Excellent problem-solving skills and a hands-on approach to development.
• Strong written and verbal communication skills for effective team collaboration and documentation.
• Experience with cGMP environments is a plus.

Benefits

• Our client offers a competitive salary, performance incentives, comprehensive health benefits, and retirement savings plan.
• Opportunities for professional development, including specialized training and conference attendance, are provided.
• Join a forward-thinking company committed to innovation and operational excellence.
• The Mahikeng, North West, ZA location provides a unique setting for industrial advancement.
• Make a significant contribution to scalable and sustainable chemical manufacturing.