Senior Process Chemist - Pharmaceutical Manufacturing

Placements24; Sandton; Presencial; ZAR 1.000.000 - 1.400.000; Jornada completa

Ventajas ofrecidas por este puesto de trabajo

Annual bonus

Medical coverage

Retirement plan

Descripción de la vacante

Placements24 is seeking an experienced Senior Process Chemist for our Sandton, Gauteng facility to lead development, optimization, and scale-up of APIs and intermediates. The role focuses on improving process efficiency, yield, safety, and sustainability from lab to commercial scale.

The ideal candidate has a PhD or MSc in Organic Chemistry, Process Chemistry, or Chemical Engineering, with 6+ years in pharmaceutical process development and scale-up, and a strong grasp of cGMP and regulatory

Formación

• Ph.D. or M.Sc. in Organic Chemistry, Process Chemistry, or Chemical Engineering.
• Minimum of 6 years of relevant experience in pharmaceutical process development and scale-up.
• Experience with cGMP environments and regulatory requirements for pharmaceutical manufacturing.

Responsabilidades

• Lead process development and optimization projects for synthesis of APIs and pharmaceutical intermediates.
• Design and execute laboratory-scale experiments to explore new routes and improve existing ones.
• Conduct process safety assessments to ensure safe scale-up (e.g., HAZOP studies).
• Develop and optimize process parameters to maximize yield, purity, and efficiency.
• Troubleshoot issues during pilot plant trials and commercial manufacturing.
• Collaborate with engineers to transfer processes from lab to pilot and commercial scale.
• Ensure compliance with cGMP, safety, and environmental regulations.
• Prepare process development reports, transfer documentation, and validation protocols.
• Stay updated on new technologies in process chemistry and pharmaceutical manufacturing.
• Mentor junior chemists and provide technical guidance to the team.

Conocimientos

Organic synthesis

Process chemistry

Scale-up experience

DoE experience

Analytical problem solving

Leadership

Communication skills

Educación

PhD or MSc in Organic Chemistry/Process Chemistry/Chemical Engineering

Herramientas

HPLC

GC

NMR

KF

DSC

Descripción del empleo

About the Role

Our client, a leading pharmaceutical manufacturer, is seeking an experienced Senior Process Chemist for their facility in Sandton, Gauteng. This role is critical for the development, optimization, and scale-up of chemical processes used in the manufacturing of active pharmaceutical ingredients (APIs) and intermediates. You will lead projects focused on improving process efficiency, yield, safety, and sustainability, ensuring that processes are robust and reproducible from laboratory to commercial scale. The ideal candidate possesses a strong background in organic chemistry, process chemistry principles, scale-up experience, and a deep understanding of chemical engineering fundamentals. This is an exceptional opportunity to contribute to the production of vital medicines and advance your career within a dynamic and quality-driven organization based in Sandton. Our client is committed to operational excellence and continuous innovation in pharmaceutical manufacturing.

Key Responsibilities

• Lead process development and optimization projects for the synthesis of APIs and pharmaceutical intermediates.
• Design and execute laboratory-scale experiments to explore new synthetic routes and improve existing ones.
• Conduct process safety assessments (e.g., HAZOP studies, reaction calorimetry) to ensure safe scale-up.
• Develop and optimize process parameters (temperature, pressure, reaction time, reagent stoichiometry) to maximize yield, purity, and efficiency.
• Troubleshoot process issues encountered during pilot plant trials and commercial manufacturing.
• Collaborate with engineers to facilitate the successful transfer of processes from laboratory to pilot plant and commercial scale.
• Ensure all process development activities comply with cGMP, safety, and environmental regulations.
• Prepare detailed process development reports, technical transfer documentation, and process validation protocols.
• Stay abreast of new technologies and methodologies in process chemistry and pharmaceutical manufacturing.
• Mentor junior chemists and provide technical guidance to the process development team.

Requirements

• Ph.D. or M.Sc. in Organic Chemistry, Process Chemistry, or Chemical Engineering with a strong focus on organic synthesis.
• Minimum of 6 years of relevant experience in pharmaceutical process development and scale-up.
• Proven expertise in synthetic organic chemistry, with a deep understanding of reaction mechanisms and kinetics.
• Demonstrated experience in optimizing chemical processes for yield, purity, safety, and cost-effectiveness.
• Hands-on experience with laboratory equipment and analytical techniques relevant to process chemistry (e.g., HPLC, GC, NMR, KF, DSC).
• Knowledge of process safety principles and risk assessment methodologies.
• Experience with cGMP environments and regulatory requirements for pharmaceutical manufacturing is essential.
• Strong problem-solving abilities and excellent attention to detail.
• Effective communication and interpersonal skills, with the ability to lead project teams.
• Experience with statistical design of experiments (DoE) is a significant advantage.

Benefits

• Our client offers a highly competitive salary, an annual bonus, comprehensive medical coverage, and a substantial retirement savings plan.
• Employees benefit from opportunities for professional development, including training programs and conference participation.
• This role requires full-time on-site presence at our Sandton facility to ensure close collaboration with manufacturing operations and direct involvement in process scale-up activities.
• We foster a dynamic and innovative work environment.