Senior Computational Chemist - Hybrid Drug Discovery

Placements24; Benoni; Hybrid; ZAR 1.200.000 - 1.800.000; Vollzeit

Benefits dieser Stelle

Health, dental, vision insurance

Retirement contributions

Hybrid work arrangement in Benoni

Professional development opportunities

Paid time off

Performance bonuses

Stimulating research environment

Zusammenfassung

Placements24 is seeking a Senior Computational Chemist to join our pharmaceutical research team in Benoni, Gauteng. The role blends drug discovery responsibilities with advanced computational methods to design and optimize novel candidates using docking, QSAR, and molecular modeling in a hybrid work setting.

You will collaborate with synthetic chemists, biologists, and pharmacologists to translate data into actionable insights, maintain computational infrastructure, and contribute to

Qualifikationen

• PhD in Computational Chemistry, Cheminformatics, Medicinal Chemistry, or related field.
• Minimum of 5 years of experience in computational chemistry within pharma/biotech.
• Proficiency with Schrödinger Suite, MOE, AutoDock, GROMACS.
• Strong understanding of molecular mechanics, quantum mechanics, and statistical mechanics.
• Excellent programming skills (Python) for scripting and data analysis.
• Excellent written and verbal communication skills.
• Ability to work independently and as part of a collaborative team.

Aufgaben

• Perform molecular modeling, docking, and virtual screening studies to identify potential drug candidates.
• Develop and apply QSAR models to guide lead optimization efforts.
• Design novel chemical entities using computational tools and cheminformatics approaches.
• Collaborate with synthetic chemists to plan synthetic routes for computationally designed molecules.
• Analyze and interpret complex data from computational simulations and experimental assays.
• Work closely with biologists and pharmacologists to understand target biology and drug mechanisms.
• Maintain and develop computational chemistry infrastructure and databases.
• Stay abreast of the latest advancements in computational chemistry and cheminformatics.
• Contribute to project strategy, scientific publications, and patent applications.
• Effectively communicate complex computational results to multidisciplinary teams.

Kenntnisse

Python

Analytical thinking

Communication

Independent work

Ausbildung

PhD in Computational Chemistry

Tools

Schrödinger Suite

MOE

AutoDock

GROMACS

Jobbeschreibung

Placements24 is seeking a Senior Computational Chemist to join our pharmaceutical research team in Benoni, Gauteng. The role blends drug discovery responsibilities with advanced computational methods to design and optimize novel candidates using docking, QSAR, and molecular modeling in a hybrid work setting.

You will collaborate with synthetic chemists, biologists, and pharmacologists to translate data into actionable insights, maintain computational infrastructure, and contribute to