Senior Bioprocess Engineer — Scale Biologics & Gmp

Placements24; Gauteng; On-site; ZAR 1,200,000 - 2,000,000; Full time

Benefits offered by this job

Competitive salary

Medical, dental, and vision insurance

Retirement plan with company contr.

Paid time off

Professional development

Job summary

Placements24 is seeking a Senior Bioprocess Engineer for our client in Vereeniging to optimize and scale biopharmaceutical manufacturing. You will design and manage bioprocess workflows, scale up with large reactors, and ensure robust production of biologics in a regulated setting.

The role requires a MSc/PhD in biochemical/chemical engineering and at least 7 years in biopharma process development, with GMP, DoE, and data-driven process improvements.

Qualifications

• MSc or PhD in Biochemical Eng, Chemical Eng, Biotechnology, or related field.
• Minimum 7 years of progressive experience in biopharmaceutical process development and manufacturing.
• Strong GMP knowledge and regulatory requirements.

Responsibilities

• Design, develop, optimize, and scale up bioprocesses for biologics.
• Operate large-scale bioreactors, cell culture systems, and downstream purification equipment.
• Conduct process validation, troubleshoot deviations, and implement CAPAs.
• Analyze process data to identify opportunities for improvement in yield, efficiency, and product quality.
• Collaborate with cross-functional teams including manufacturing, QA, and regulatory affairs.

Skills

Biochemical engineering

Process development

Scale-up bioprocessing

GMP compliance

DoE

Statistical analysis

Cell culture

Process modeling

Education

MSc/PhD in Biochemical Eng

Tools

DoE software

Job description

About the Role

Our client is seeking a seasoned Senior Bioprocess Engineer to join their expanding operations in Vereeniging. This role is instrumental in optimizing and scaling up biopharmaceutical manufacturing processes, ensuring the efficient and robust production of therapeutic proteins and other biologics. You will design, implement, and manage bioprocessing workflows, troubleshoot complex manufacturing challenges, and contribute to the development of next-generation bioprocessing technologies. The ideal candidate will possess a strong foundation in biochemical engineering principles, extensive experience with large-scale bioreactors and downstream processing, and a commitment to driving operational excellence in a highly regulated industry, all within a collaborative and innovation-focused setting.

Key Responsibilities

• Design, develop, optimize, and scale up bioprocesses for the production of biologics.
• Manage and operate large-scale bioreactors, cell culture systems, and downstream purification equipment.
• Conduct process validation, troubleshoot deviations, and implement corrective and preventative actions (CAPAs).
• Analyze process data to identify opportunities for improvement in yield, efficiency, and product quality.
• Collaborate with cross-functional teams, including manufacturing, quality assurance, and regulatory affairs.

Requirements

• MSc or PhD in Biochemical Engineering, Chemical Engineering, Biotechnology, or a related field.
• Minimum of 7 years of progressive experience in biopharmaceutical process development and manufacturing.
• In-depth knowledge of upstream (cell culture) and downstream (purification) bioprocessing operations.
• Experience with process modeling, statistical analysis, and Design of Experiments (DoE).
• Strong understanding of Good Manufacturing Practices (GMP) and regulatory requirements.

Benefits

• Highly competitive salary and performance-based bonus structure.
• Comprehensive medical, dental, and vision insurance coverage.
• Retirement savings plan with company contributions.
• Generous paid time off and opportunities for professional development.
• Key role in advancing biopharmaceutical production in Vereeniging.