Lead DMPK Scientist: ADME Strategy & Leadership

Placements24; Mbombela (Nelspruit); Vor Ort; ZAR 1.200.000 - 1.800.000; Vollzeit

Benefits dieser Stelle

Performance bonus

Medical insurance

Retirement plan

Paid time off

Zusammenfassung

Placements24 is seeking a Lead Research Scientist in Nelspruit to guide the DMPK department, designing and overseeing preclinical ADME studies and regulatory contributions.

The role requires a PhD and at least 7 years in drug metabolism, with leadership experience and LC-MS/MS bioanalytical expertise. You will drive strategic data interpretation and cross-functional collaboration in a premier research setting.

Qualifikationen

• Ph.D. in Pharmaceutical Sciences or related discipline.
• Minimum of 7 years of progressive experience in drug metabolism and pharmacokinetics in pharma.
• Proven experience in managing scientific projects and leading teams.
• Extensive knowledge of in vitro ADME assays (e.g., metabolic stability, CYP inhibition/induction, transporter assays).
• Hands-on experience with bioanalytical techniques (LC-MS/MS).
• Strong understanding of regulatory requirements and GLP principles.
• Excellent analytical, problem-solving and communication skills.
• Experience in candidate selection and regulatory filings is desirable.
• Ability to work in a collaborative research environment in Nelspruit.

Aufgaben

• Lead and manage a team of scientists conducting in vitro and in vivo DMPK studies.
• Design and oversee ADME studies (absorption, distribution, metabolism, excretion) for drug candidates.
• Develop and validate bioanalytical methods for drugs and metabolites.
• Interpret complex DMPK data and integrate with other findings.
• Provide strategic input on candidate selection based on DMPK properties.
• Ensure compliance with regulatory guidelines (FDA/EMA) and GLP standards.
• Collaborate with chemistry, toxicology and pharmacology teams.
• Contribute to regulatory submissions and publications.
• Stay updated on DMPK advances and technologies.

Kenntnisse

DMPK leadership

In vitro ADME

Bioanalytical methods

Regulatory understanding

Data interpretation

Team leadership

Ausbildung

PhD in Pharmaceutical Sciences

Tools

LC-MS/MS

Jobbeschreibung

Placements24 is seeking a Lead Research Scientist in Nelspruit to guide the DMPK department, designing and overseeing preclinical ADME studies and regulatory contributions.

The role requires a PhD and at least 7 years in drug metabolism, with leadership experience and LC-MS/MS bioanalytical expertise. You will drive strategic data interpretation and cross-functional collaboration in a premier research setting.