Pharma Process Engineer: Hybrid Role, GMP & Scale-Up

Placements24; Mbombela (Nelspruit); Hybrid; ZAR 900,000 - 1,200,000; Full time

Benefits offered by this job

Medical aid

Pension fund

Life assurance

Job summary

Placements24 is seeking a Chemical Engineer to join the Process Development team in Nelspruit, Mpumalanga. The role focuses on development, optimization, and scale-up of synthesis and purification for APIs and intermediates within a GMP environment.

You will work in a state-of-the-art lab and pilot plant, collaborating with chemists and formulation scientists to deliver safe, reproducible manufacturing. A strong background in organic chemistry, reaction engineering, crystallization, and

Qualifications

• Bachelor’s or Master’s degree in Chemical Engineering with strong GMP experience.
• At least 5 years of pharmaceutical process development or API manufacturing experience.
• Strong knowledge of organic chemistry, kinetics and thermodynamics.
• Experience with lab-to-pilot scale-up and analytical method development.
• Proficient in process simulation software (Aspen Plus or CHEMCAD).

Responsibilities

• Develop and optimize API synthesis routes for scale-up from lab to pilot plant.
• Design experiments and perform process scale-up, including crystallization and purification.
• Model and simulate processes to predict performance and optimize operating conditions.
• Troubleshoot issues, identify root causes, and implement improvements.
• Prepare process descriptions, P&IDs, and equipment specifications.
• Collaborate with manufacturing for tech transfer and ensure GMP compliance.
• Conduct PHAs and implement safety measures.
• Document results and present findings to cross-functional teams.

Skills

Organic chemistry

Reaction engineering

Crystallization

Separation technologies

Process modeling

GMP familiarity

Education

Bachelor's or Master's in Chemical Engineering

Tools

Aspen Plus

CHEMCAD

Job description

Placements24 is seeking a Chemical Engineer to join the Process Development team in Nelspruit, Mpumalanga. The role focuses on development, optimization, and scale-up of synthesis and purification for APIs and intermediates within a GMP environment.

You will work in a state-of-the-art lab and pilot plant, collaborating with chemists and formulation scientists to deliver safe, reproducible manufacturing. A strong background in organic chemistry, reaction engineering, crystallization, and