Lead Synthetic Organic Chemist - Pharmaceutical Research

Placements24; Rustenburg; Presencial; ZAR 1 800 000 - 2 600 000; Tempo integral

Vantagens oferecidas por esta oferta de emprego

Competitive salary package

Health benefits

Retirement plan

Career development opportunities

Resumo da oferta

Placements24 in Rustenburg, North West, ZA, seeks a Lead Synthetic Organic Chemist to guide multi-step syntheses and develop scalable routes for novel therapeutics. You will mentor chemists, design rich synthetic strategies, and collaborate with medicinal chemists to advance drug candidates in a fast-paced R&D setting.

The role demands a Ph.D. in Organic Chemistry with at least 5 years of experience in pharmaceutical research, strong leadership, and a track record of publications or patents.

Qualificações

• Ph.D. in Organic Chemistry or closely related field is required.
• Minimum 5 years of post-doctoral or industrial experience in synthetic organic chemistry.
• Proven leadership experience managing chemistry projects and teams.
• Strong knowledge of a wide range of organic reactions and methodologies.
• Experience with retrosynthetic analysis and route design.
• Hands-on use of modern spectroscopic and chromatographic techniques.
• Solid understanding of stereochemistry and asymmetric synthesis.
• Track record of publications and/or patents.

Responsabilidades

• Lead and manage synthetic organic chemistry projects focused on new chemical entities.
• Design and execute multi-step syntheses to access target molecules.
• Optimize reaction conditions to improve yield and purity.
• Develop purification strategies for complex mixtures.
• Troubleshoot challenges and innovate solutions.
• Characterize compounds using NMR, MS, HPLC, IR.
• Collaborate with medicinal chemists on SAR studies.
• Mentor junior chemists and contribute to IP through patents.

Conhecimentos

Leadership

Retrosynthesis

Route design

Spectroscopy

Stereochemistry

Publications

Mentoring

Formação académica

Ph.D. in Organic Chemistry

Descrição da oferta de emprego

About the Role

Our client, a prominent pharmaceutical research company located in **Rustenburg, North West, ZA**, is seeking a highly skilled and innovative Lead Synthetic Organic Chemist. This role is crucial for the discovery and development of novel small molecule therapeutics. You will lead a team of chemists in designing and executing complex multi-step syntheses of target molecules, optimizing reaction conditions, and developing robust scale-up processes. The position demands a profound understanding of modern synthetic methodologies, retrosynthetic analysis, and purification techniques. You will collaborate closely with medicinal chemists, biologists, and process chemists to advance drug candidates through the discovery pipeline. The ideal candidate possesses a strong track record of publications, patent contributions, and hands‑on experience in a drug discovery setting. This position is based at our state‑of‑the‑art research and development facility in **Rustenburg, North West, ZA**.

Key Responsibilities

• Lead and manage synthetic organic chemistry projects focused on the discovery of new chemical entities.
• Design and execute complex multi‑step synthetic routes to access target molecules, including natural products and novel heterocyclic compounds.
• Optimize reaction conditions to improve yield, purity, and efficiency.
• Develop and implement purification strategies (chromatography, crystallization) for complex mixtures.
• Troubleshoot synthetic challenges and develop innovative solutions.
• Characterize synthesized compounds using modern analytical techniques (NMR, MS, HPLC, IR).
• Collaborate with medicinal chemists to design structure‑activity relationship (SAR) studies.
• Mentor and supervise junior synthetic chemists, fostering a collaborative team environment.
• Contribute to the generation of intellectual property through patent applications.

Requirements

• Ph.D. in Organic Chemistry or a closely related field.
• Minimum of 5 years of post‑doctoral or industrial experience in synthetic organic chemistry, preferably in pharmaceutical research.
• Demonstrated leadership experience in managing chemistry projects and teams.
• Extensive knowledge of a wide range of organic reactions and synthetic methodologies.
• Proficiency in retrosynthetic analysis and route design.
• Hands‑on experience with modern spectroscopic and chromatographic techniques for compound characterization and purification.
• Strong understanding of stereochemistry and asymmetric synthesis.
• Excellent problem‑solving skills and a creative approach to synthetic challenges.
• Strong written and verbal communication skills, with a record of publications and/or patents.
• Ability to work effectively in a fast‑paced, collaborative research environment.
• Willingness to work full‑time at our facility in **Rustenburg, North West, ZA**.

Benefits

Our client offers a competitive salary package, comprehensive health benefits, retirement plan, and performance‑based incentives. We provide excellent opportunities for professional development, training, and career advancement within a leading pharmaceutical research organization. Employees have access to advanced laboratory facilities and cutting‑edge technology. Join our innovative team in **Rustenburg, North West, ZA** and contribute to the development of life‑changing medicines.