Senior Synthetic Organic Chemist

Placements24; Bloemfontein; Hybrid; ZAR 900,000 - 1,200,000; Full time

Benefits offered by this job

Competitive salary

Medical, disability, and life保险

Retirement savings plan

Paid time off and holidays

Professional development and CONFERENC

Conference attendance

Modern labs and instrumentation

Collaborative research environment

Impactful pharmaceutical development

Job summary

Placements24 in Bloemfontein, South Africa, seeks a Senior Synthetic Organic Chemist to lead design and execution of multi-step syntheses for potential therapeutics. You will optimize conditions, characterize products using NMR, MS, and HPLC, and troubleshoot challenging problems in collaboration with medicinal and analytical chemists.

The role emphasizes independence and teamwork within a state-of-the-art R&D laboratory, contributing to drug discovery programs and professional growth.

Qualifications

• PhD in Synthetic Organic Chemistry or closely related field.
• 5+ years of post-doctoral or industry experience in synthetic organic chemistry.
• Expertise in modern synthetic methodologies including asymmetric synthesis and organometallic chemistry.
• Hands-on experience with a wide range of synthetic reactions and purification techniques.
• Proficiency in NMR, MS, and chromatography for structural elucidation.
• Experience developing scalable synthetic routes is desirable.
• Strong problem-solving, organizational, and time management skills.
• Excellent written and verbal communication for collaboration and reporting.
• Ability to work independently and in a team in Bloemfontein.

Responsibilities

• Design and execute complex multi-step synthetic routes to novel organic molecules.
• Optimize reaction conditions to improve yield, purity, and scalability.
• Characterize synthesized compounds using modern analytical techniques (NMR, MS, HPLC).
• Troubleshoot challenging synthetic problems and develop innovative solutions.
• Collaborate with medicinal chemists to generate analogues for SAR studies.
• Work with process chemists to develop scalable and robust synthetic routes.
• Maintain detailed laboratory notebooks and research reports.
• Stay current with advancements in synthetic organic chemistry literature.
• Ensure adherence to laboratory safety regulations and procedures.

Skills

Multi-step synthesis

Asymmetric synthesis

Organometallic chemistry

Problem solving

Education

Ph.D. in Synthetic Organic Chemistry

Tools

NMR spectroscopy

Mass spectrometry

Chromatography

Job description

About the Role

Our client, a prominent pharmaceutical research and development company situated in Bloemfontein, Free State , is seeking an accomplished Senior Synthetic Organic Chemist to enhance their Scientific Research & Development capabilities. This role is central to the design and synthesis of novel small molecules with therapeutic potential. The successful candidate will be responsible for planning and executing complex multi-step syntheses, optimizing reaction conditions, and characterizing synthesized compounds. You will work in a state-of-the-art laboratory, collaborating closely with medicinal chemists, analytical chemists, and biologists to support drug discovery programs. This is an excellent opportunity to contribute to the advancement of new medicines and grow your career within a leading R&D organization. We are looking for a creative and highly skilled chemist with a passion for organic synthesis and a strong problem-solving aptitude. Join our team in Bloemfontein and contribute to impactful pharmaceutical innovation.

Key Responsibilities

• Design and execute complex multi-step synthetic routes to novel organic molecules.
• Optimize reaction conditions to improve yield, purity, and scalability of synthetic processes.
• Characterize synthesized compounds using modern analytical techniques (e.g., NMR, MS, HPLC).
• Troubleshoot challenging synthetic problems and develop innovative solutions.
• Collaborate effectively with medicinal chemists to generate analogues for SAR studies.
• Work with process chemists to develop scalable and robust synthetic routes.
• Maintain detailed and accurate laboratory notebooks and research reports.
• Stay current with the latest advancements in synthetic organic chemistry literature and techniques.
• Ensure adherence to all laboratory safety regulations and procedures.

Requirements

• Ph.D. in Synthetic Organic Chemistry or a closely related field.
• Minimum of 5 years of post-doctoral or industry experience in synthetic organic chemistry.
• Proven expertise in modern synthetic methodologies, including asymmetric synthesis and organometallic chemistry.
• Strong hands-on experience with a wide range of synthetic reactions and purification techniques.
• Proficiency in structural elucidation using NMR spectroscopy, mass spectrometry, and chromatography.
• Experience in developing scalable synthetic routes is highly desirable.
• Excellent problem-solving, organizational, and time management skills.
• Strong written and verbal communication skills for effective collaboration and reporting.
• Ability to work independently and contribute positively to a team environment in Bloemfontein .

Benefits

• Competitive salary and performance bonus structure.
• Comprehensive medical, disability, and life insurance.
• Retirement savings plan with generous employer contribution.
• Paid time off and company holidays.
• Opportunities for professional development and conference attendance in Bloemfontein .
• Access to modern synthetic chemistry laboratories and instrumentation.
• A collaborative research environment focused on innovation.
• Chance to contribute to the development of life-changing pharmaceuticals.