Flow Chemistry Researcher – APIs & Continuous Processing

Council for Scientific and Industrial Research (CSIR); Pretoria; On-site; ZAR 600,000 - 1,000,000; Full time

Benefits offered by this job

Learning and development opportunities

Competitive remuneration packages

CSIR Excellence Awards

Job summary

The Council for Scientific and Industrial Research (CSIR) in Pretoria seeks a Researcher in Pharmaceutical Technologies to advance flow chemistry process development for APIs and related intermediates. The role includes telescoping steps to deliver continuous batch/flow-hybrid routes and integration of in-line analytics, based in the Chemicals Cluster.

The incumbent will lead translational development, scale processes, supervise postgraduate students, and contribute to peer-reviewed

Qualifications

• Master's degree in flow chemistry or process chemistry/engineering.
• Five years of laboratory-based flow experience.
• Experience in flow-based process development for small molecule APIs.
• Experience in multi-step flow synthesis with telescoping steps.
• Experience with inline or at-line analytics in developed processes.
• Design and development of modules/downstream processing for continuous flow systems.
• Interest in ML-guided reaction optimization.
• Ability to adapt, multitask and perform under pressure.
• Strong analytical and problem-solving skills.
• SAQA evaluation required for international qualifications.

Responsibilities

• Develop and optimize APIs and related intermediates using flow chemistry.
• Telescoping steps to form continuous batch/flow-hybrid routes and scale progressively.
• Provide solutions to reaction challenges in flow chemistry and develop novel reactor modules.
• Implement inline and/or at-line monitoring of reactor systems.
• Pursue independent research aligned with CSIR cluster objectives.
• Supervise and/or co-supervise postgraduate students.
• Contribute to peer-reviewed publications, lead author on at least one per year.
• Collaborate with CSIR teams and external academic/industry partners.
• Engage in independent research aligned with strategic objectives.
• Contribute to scholarly publications as lead author annually.

Skills

Flow chemistry

Process chemistry

Multi-step synthesis

Inline analytics

Module design

Downstream processing

ML optimization

Adaptability

Team collaboration

Analytical skills

Education

Master's degree in flow chemistry or process chemistry/engineering

Job description

The Council for Scientific and Industrial Research (CSIR) in Pretoria seeks a Researcher in Pharmaceutical Technologies to advance flow chemistry process development for APIs and related intermediates. The role includes telescoping steps to deliver continuous batch/flow-hybrid routes and integration of in-line analytics, based in the Chemicals Cluster.

The incumbent will lead translational development, scale processes, supervise postgraduate students, and contribute to peer-reviewed