VP, Rare Disease Clinical Development

Marrow Therapeutics; Watertown (MA); On-site; USD 350,000 - 500,000; Full time

Job summary

Marrow Therapeutics in Watertown, MA seeks a Vice President, Clinical Development to shape and lead the clinical development strategy for rare disease, hematology, and hematologic oncology programs. You will translate scientific insights into rigorous development plans and guide programs through milestones that inform patient benefit and portfolio decisions.

You will lead cross-functional teams, oversee study concepts, endpoints, dose selection, and regulatory interactions, with a hands-on

Qualifications

• MD, DO, PhD, or equivalent advanced degree in a clinical or scientific discipline.
• 15+ years of relevant drug development experience including leadership of clinical development programs and strategy.
• Direct clinical development experience in rare disease, hematology, or hematologic oncology.
• Demonstrated ownership of clinical development plans and milestones with decisions explained.
• Strong knowledge of clinical trial methodology (protocol design, endpoints, dose selection, safety, translational data).
• Experience translating biomarker findings into patient-selection strategies and development decisions.
• Experience contributing to regulatory submissions and agency interactions.
• Proven ability to lead cross-functional teams and make sound recommendations under uncertainty.
• Knowledge of GCP and clinical study oversight in specialized patient populations.
• Excellent communication skills with investigators, partners, and executives.
• Collaborative, accountable leadership to drive critical work in a fast-moving environment.

Responsibilities

• Define development objectives, indication priorities, and key milestones aligned with disease biology and portfolio objectives.
• Guide study concepts, protocols, eligibility, endpoints, and dose-selection strategies to establish safety and clinical benefit.
• Partner with Translational Science and Biometrics to integrate biomarkers and patient selection into studies.
• Align Clinical Operations, Regulatory Affairs, Safety, and other functions around integrated development plans and timelines.
• Collaborate with investigators and sites on enrollment strategy, CRO oversight, and protocol execution.
• Ensure timely review of emerging findings and inform study conduct and development decisions.
• Engage with regulatory affairs on briefing materials and agency interactions that shape the development path.
• Represent Marrow in advisory boards and scientific forums; mentor colleagues and contributors.

Skills

Clinical development leadership

Cross-functional leadership

Regulatory submissions

Trial design & endpoints

Biomarker-driven strategy

GCP & trial oversight

Strategic program leadership

Communication with stakeholders

Education

MD/DO/PhD or equivalent

Job description

Marrow Therapeutics in Watertown, MA seeks a Vice President, Clinical Development to shape and lead the clinical development strategy for rare disease, hematology, and hematologic oncology programs. You will translate scientific insights into rigorous development plans and guide programs through milestones that inform patient benefit and portfolio decisions.

You will lead cross-functional teams, oversee study concepts, endpoints, dose selection, and regulatory interactions, with a hands-on