VP, Biotherapeutics Discovery – Oncology Platform Leader

Stipple Bio; Cambridge (MA); On-site; USD 250,000 - 350,000; Full time

Job summary

Stipple Bio, Inc. is a private biotechnology company pioneering epitope-level precision oncology.

The Vice President, Biotherapeutics Discovery will build and direct the platform technology for target discovery, biotherapeutics discovery, and protein engineering, leading a multidisciplinary team in Cambridge, MA to advance candidates toward IND with cross-functional collaborations across modalities like antibodies, ADCs, and TCEs.

Qualifications

• PhD in Immunology or related discipline required.
• 12+ years biotech/pharma drug discovery experience with substantial antibody therapeutics focus.
• Deep expertise across antibody discovery platforms and protein engineering including TCE and multispecific formats.
• Proven track record of advancing biologics candidates from discovery into development, ideally in oncology.
• Demonstrated leadership, building and mentoring high-performing discovery teams.

Responsibilities

• Build and lead a high-performing platform technology, target discovery, antibody discovery, and protein engineering teams.
• Define and drive antibody discovery and engineering strategy from target validation through lead nomination.
• Lead design and engineering of therapeutic molecules across modalities (antibodies, ADCs, TCEs).
• Oversee target and antibody discovery campaigns using display technologies and in silico/ML-guided design.
• Oversee protein engineering including affinity maturation, format engineering, and developability optimization.
• Scale platform technologies, drive throughput and quality, evaluate external platform partnerships.
• Partner with translational biology, CMC, clinical and program leadership to advance candidates toward IND.
• Contribute to pipeline strategy and resource prioritization at executive level.

Skills

Leadership

Biotech

Antibody discovery

Protein engineering

ML design

Education

PhD in Immunology

Job description

Stipple Bio, Inc. is a private biotechnology company pioneering epitope-level precision oncology.

The Vice President, Biotherapeutics Discovery will build and direct the platform technology for target discovery, biotherapeutics discovery, and protein engineering, leading a multidisciplinary team in Cambridge, MA to advance candidates toward IND with cross-functional collaborations across modalities like antibodies, ADCs, and TCEs.