Upstream/Downstream Manufacturing Supervisor

Pharma Universe; United States; On-site; USD 45,000 - 50,000; Full time

Job summary

A leading company in the pharmaceutical industry is seeking Manufacturing Supervisors for its new facility in Chicago. The roles involve managing production activities in Drug Substance Manufacturing, ensuring compliance with industry standards, and leading a team for efficiency and quality. Ideal candidates will hold a relevant Bachelor's degree and have 3-5 years of manufacturing experience in a cGMP environment.

Qualifications

• Minimum 3-5 years in biologics or biopharmaceutical manufacturing.
• Hands-on experience with aseptic processing.
• Prior experience supervising manufacturing teams within a cGMP environment.

Responsibilities

• Lead and supervise daily production activities complying with cGMPs.
• Oversee E. coli cell culture fermentation and protein purification.
• Train employees on cleanroom behavior and operational protocols.

Skills

Supervising

Production Management

Cell Culture

Protein Purification

Aseptic Processing

Education

Bachelor's degree in Biotechnology, Biochemistry, Microbiology, Chemical Engineering, or a related field

Job description

Upstream/Downstream Manufacturing Supervisor

Upstream/Downstream Manufacturing Supervisor

1 day ago Be among the first 25 applicants

This range is provided by Pharma Universe. Your actual pay will be based on your skills and experience — talk with your recruiter to learn more.

Base pay range

$45.00/yr - $50.00/yr

We're building a high-impact Drug Substance Manufacturing team at a brand-new, state-of-the-art site in Chicago - and looking for 2 new Manufacturing Supervisors who will lead the 2nd and 3rd shift Drug Substance teams.

The appointed candidate will play a critical role in managing the production activities for Biologics Manufacturing for the 2nd or 3rd shift operation. This includes supervising cell culture fermentation, protein purification, and aseptic processing to produce high-quality drug substances.

Location: City of Chicago

Hours: Monday-Friday 2pm-10pm or 10pm-6am

Pay: $45-$50/hr + bonus + 1.5x overtime.

Responsibilities:

• Lead and supervise daily production activities in compliance with cGMPs, SOPs, and Environmental Health and Safety (EHS) guidelines
• Oversee E. coli cell culture fermentation, centrifugation, and homogenization processes
• Manage protein purification using chromatography columns and various filtration systems
• Ensure successful formulation, aseptic filtration, and visual inspection of drug product syringes
• Coordinate the preparation, washing, and sterilization of machine parts and materials for aseptic processing areas
• Report production status and progress to supervisors and other departments
• Coordinate production batch scheduling with management, adjusting schedules as necessary to meet production needs and timelines
• Implement organizational systems to efficiently allocate workload, maintain compliance, and improve productivity across shifts
• Train employees on cleanroom behavior, equipment operation, and detailed process instructions
• Develop and maintain comprehensive training materials and ensure staff remain up-to-date on operational protocols and compliance requirements
• Author and revise Batch Records, Standard Operating Procedures (SOPs), and other production documentation to integrate cGMPs and optimize process efficiency
• Ensure all manufacturing activities adhere to internal and external regulatory standards, supporting audits and inspections as needed
• Participate in the qualification of drug product manufacturing suites, ensuring successful validation and qualification batch execution
• Procure necessary materials and supplies with a focus on cost reduction and resource
• Track and manage inventory to support continuous production flow, while identifying and implementing strategies to minimize waste and reduce material costs
• Identify opportunities for efficiency improvements and lead initiatives to enhance process performance
• Implement best practices and support continuous improvement in production quality and throughput
  
  

Experience/Qualifications:

• Bachelor's degree in Biotechnology, Biochemistry, Microbiology, Chemical Engineering, or a related field
• Minimum 3-5 years in biologics or biopharmaceutical manufacturing, with expertise in cell culture, fermentation, and protein purification
• Hands-on experience with aseptic processing and equipment preparation
• Prior experience supervising or coordinating manufacturing teams within a cGMP environment

Seniority level

• Seniority level

  Mid-Senior level

Employment type

• Employment type

  Full-time

Job function

• Job function

  Manufacturing

• Industries

  IT Services and IT Consulting

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