Translational Neurogenetics Fellow - RNA & Gene Editing

Mayo Foundation for Medical Education and Research; Rochester (MN); On-site; USD 60,000 - 85,000; Full time

Benefits offered by this job

Medical options

Dental coverage

Vision coverage

HSA/FSAs

Retirement plan

Job summary

The Cousin Lab at Mayo Clinic is seeking a postdoctoral fellow to contribute to a growing rare disease therapeutics program with an initial emphasis on POLR2A-related disorders.

This work also supports broader efforts in ALS and other monogenic neurologic conditions, using iPSC-derived neural models, genome editing, and sequencing-based biomarkers in collaboration with Mayo Clinic precision medicine and external partners.

Qualifications

• Ph.D. or MD/PhD in a relevant field with strong training in neuroscience or genomics.
• Experience in cell-based disease modeling, molecular biology, and therapeutic development.
• Strong wet-lab skills, sequencing workflows, and imaging capabilities.
• Ability to analyze, interpret, and communicate complex data.
• Proven ability to work collaboratively in translational research environments.

Responsibilities

• Develop patient-derived and engineered disease models including iPSCs and neural cells.
• Design and run assays to define variant effects and disease mechanisms.
• Develop RNA-targeted and gene-editing strategies and assess therapeutic approaches.
• Integrate genomic data with functional readouts to prioritize therapies.
• Coordinate with clinicians, core facilities, and external partners for translational work.
• Prepare figures, manuscripts, and grant applications; mentor junior team members.

Skills

Wet-lab skills

Cell culture

Molecular biology

Assay development

Sequencing workflows

Microscopy

Data analysis

Python/R

Communication

Team collaboration

Education

Ph.D., MD/PhD

Neuroscience

Genomics

Stem cell biology

Tools

Prism

R

Python

Genome sequencing

Job description

The Cousin Lab at Mayo Clinic is seeking a postdoctoral fellow to contribute to a growing rare disease therapeutics program with an initial emphasis on POLR2A-related disorders.

This work also supports broader efforts in ALS and other monogenic neurologic conditions, using iPSC-derived neural models, genome editing, and sequencing-based biomarkers in collaboration with Mayo Clinic precision medicine and external partners.