Research Fellow, Rare Neurogenetics & Gene Therapy

Mayo Career Site UK; Rochester (MN); On-site; USD 55,000 - 75,000; Full time

Job summary

The Cousin Lab at Mayo Clinic is seeking a postdoctoral fellow to lead experimental and analytical work in a growing rare disease program, focusing initially on POLR2A-related disorders. The role emphasizes patient-derived models, variant interpretation, RNA-targeted therapies, and gene editing, with collaboration across core facilities and external partners.

You will drive model development, data integration, and translational effort, while mentoring junior staff and preparing manuscripts and

Responsibilities

• Lead experimental and analytical components of translational rare disease projects.
• Develop and characterize patient-derived and engineered disease models.
• Define variant effects and disease mechanisms.
• Design and evaluate RNA-targeted and gene-editing strategies.
• Integrate genomic, functional, and clinical data to prioritize treatments.
• Coordinate with collaborators to align samples, models, and workflows.
• Prepare figures, reports, manuscripts, and grant proposals; mentor juniors.

Skills

Wet-lab skills

Data analysis

Grant writing

Scientific communication

Mentorship

Tools

CRISPR

iPSC technology

Sequencing

Job description

The Cousin Lab at Mayo Clinic is seeking a postdoctoral fellow to lead experimental and analytical work in a growing rare disease program, focusing initially on POLR2A-related disorders. The role emphasizes patient-derived models, variant interpretation, RNA-targeted therapies, and gene editing, with collaboration across core facilities and external partners.

You will drive model development, data integration, and translational effort, while mentoring junior staff and preparing manuscripts and