Translational Immunology Scientist — T‑Cell Focus

Flagship Pioneering; Cambridge (MA); On-site; USD 100,000 - 182,000; Full time

Benefits offered by this job

Healthcare coverage

Annual incentive program

Retirement benefits

Other benefits

Job summary

Flagship Pioneering's Translational Sciences team in Cambridge, MA seeks a Scientist/Senior Scientist focused on T-cell biology to bridge early research and clinical development.

You will contribute to pharmacodynamic biomarker discovery, human dose projection, and assay development, collaborating with leaders to expand immunology programs while advancing data-driven pharmacology insights.

Qualifications

• Bachelor or Master of Science in biology, immunology, pharmacology or equivalent with 5+ years in a lab; PhD with 2+ years in industry.
• Experience with ex-vivo assay development in rodent, NHP and human tissues/plasma/whole blood.
• Experience with in vitro T cell differentiation (e.g. Treg, Th17).
• Experience using flow cytometry for phenotyping whole blood, primary T cell culture, etc.
• Sterile cell culture techniques for growth/maintenance of cell lines and primary cells.
• Hands-on experience isolating/manipulating primary cells for downstream analyses (MSD/ELISA, FACS, westerns, qPCR, histology).
• Ability to think critically and analyze data; capable of independent or team work across therapeutic areas.

Responsibilities

• Deliver datasets informing translational direction of drug discovery programs (pharmacodynamic biomarkers, human dose predictions).
• Contribute to immunology/translational research goals and program strategies.
• Collaborate on capability building to support immunology and translational needs.
• Communicate plans and data to colleagues with diverse scientific backgrounds.
• Support prioritized activities within the drug discovery group and pursue personal interests.
• Demonstrate curiosity, strong work ethic, and ability to work solo or in teams.

Skills

Ex-vivo assay development

In vitro T cell differentiation

Flow cytometry

Sterile cell culture techniques

Primary cell isolation

Data analysis

Cross-functional collaboration

Education

Bachelor or Master of Science in biology/immunology/pharmacology

Ph.D. in biology/immunology/pharmacology (with 2+ years industry)

Tools

Flow cytometry instrumentation

MSD/ELISA

Western blot

qPCR

Job description

Flagship Pioneering's Translational Sciences team in Cambridge, MA seeks a Scientist/Senior Scientist focused on T-cell biology to bridge early research and clinical development.

You will contribute to pharmacodynamic biomarker discovery, human dose projection, and assay development, collaborating with leaders to expand immunology programs while advancing data-driven pharmacology insights.