Structural Biologist (R5-R7)

Biophysical Society; San Diego (CA); On-site; USD 168,000 - 179,000; Full time

Job summary

A leading global healthcare company seeks a Structural Biologist to support structure-based drug discovery projects. This role involves performing structure determination for GPCRs and requires a Ph.D. along with specialized experience in biophysics and protein engineering. Candidates will utilize advanced techniques in structural biology to aid in pharmaceutical development while collaborating with multidisciplinary teams.

Benefits

401(k)

Health benefits

Flexible spending accounts

Life insurance

Well-being programs

Qualifications

• Minimum of 2 years' experience in GPCR biology and structure-based research.
• Expertise in structure determination by X-ray crystallography or cryo-EM.
• Proficiency with HPLC/FPLC systems.

Responsibilities

• Perform structure determination and drug design for GPCR and membrane protein targets.
• Apply biochemical, biophysical, and computational techniques for high-quality reagents.
• Develop approaches to SBDD incorporating data from multiple teams.

Skills

Biochemical techniques

Biophysical techniques

Computational tools

Protein engineering

Molecular cloning

Protein expression

Chromatographic methods

Education

Ph.D. in Structural Biology, Biophysics, Biochemistry, Chemistry

Tools

CCP4

Phenix

COOT

PyMol

Chimera

Job description

At Lilly, we unite caring with discovery to make life better for people around the world. We are a global healthcare leader headquartered in Indianapolis, Indiana. Our employees work to discover and bring life-changing medicines to those who need them, improve the understanding and management of disease, and give back to our communities through philanthropy and volunteerism. We prioritize our work and put people first.

Job Title: Structural Biologist (R5-R7)

Location: San Diego, CA

Eli Lilly and Company is seeking a Structural Biologist to support structure-based drug discovery (SBDD) projects focused on G protein-coupled receptors (GPCRs). Responsibilities include:

1. Perform structure determination and drug design for GPCR and membrane protein targets as well as soluble protein targets.
2. Apply biochemical, biophysical, and computational techniques to accelerate the generation of high-quality reagents for X-ray crystallography and cryo-EM studies.
3. Determine structures and co-complex structures of protein targets for small-molecule and antibody therapeutics design.
4. Develop integrative approaches to SBDD incorporating data from structural biology, biophysics, protein biochemistry, and medicinal chemistry teams.

Qualifications:

• Ph.D. in Structural Biology, Biophysics, Biochemistry, Chemistry, or related field.
• Minimum of 2 years' experience in GPCR biology, pharmacology, and structure-based research.
• Experience with protein engineering, biochemistry, and structure determination by X-ray crystallography or cryo-EM.
• Construct design, molecular cloning, and protein expression/purification expertise.
• Proficiency with chromatographic methods and HPLC/FPLC systems.
• Experience with SDS-PAGE, Western blot, thermal shift assays, and ELISA.
• Knowledge of computational tools such as CCP4, Phenix, COOT, PyMol, and Chimera.

Part-time telecommuting may be permitted. Up to 10% domestic and international travel required.

Compensation and Application:

Salary Range: $168,709 - $178,709 per year.

To apply, visit https://jobsearch.lilly.com/ and enter requisition number R-84158, or send your resume and cover letter to Beth L. Berry at Lilly Corporate Center, Indianapolis, IN 46285.

Additional Information:

Lilly is committed to diversity and inclusion, providing accommodations for applicants with disabilities, and fostering an inclusive work environment through Employee Resource Groups (ERGs).

Actual compensation depends on education, experience, skills, and location. Full-time employees are eligible for bonuses and comprehensive benefits, including 401(k), pension, health benefits, flexible spending accounts, life insurance, time off, and well-being programs. Lilly reserves the right to modify its programs at its discretion.