Structural Biologist (R5-R7)

Eli Lilly and Company; San Diego (CA); On-site; USD 168,000 - 179,000; Full time

Job summary

An established industry player is seeking a Structural Biologist to join their innovative team in San Diego. This role focuses on structure-based drug discovery, particularly for G protein-coupled receptors (GPCRs). You will engage in cutting-edge research, applying your expertise in protein engineering and biochemistry to design life-changing therapeutics. Collaborating with multidisciplinary teams, you will utilize advanced techniques like X-ray crystallography and cryo-EM to drive impactful discoveries. If you are passionate about making a difference in global health and thrive in a collaborative environment, this opportunity is perfect for you.

Qualifications

• Ph.D. required in relevant field with 2+ years of experience in GPCR biology.
• Experience in protein structure determination via X-ray crystallography or cryo-EM is essential.

Responsibilities

• Support structure-based drug discovery projects focused on GPCRs.
• Apply biochemical and computational techniques for protein structure determination.

Skills

GPCR biology

protein engineering

protein biochemistry

structure determination

computational tools for protein structure

molecular cloning

chromatographic methods

SDS-PAGE

Western blot

thermal shift assays

ELISA

Education

Ph.D. in Structural Biology

Ph.D. in Biophysics

Ph.D. in Biochemistry

Ph.D. in Chemistry

Tools

CCP4

Phenix

COOT

PyMol

Chimera

Job description

At Lilly, we unite caring with discovery to make life better for people around the world. We are a global healthcare leader headquartered in Indianapolis, Indiana. Our employees around the world work to discover and bring life-changing medicines to those who need them, improve the understanding and management of disease, and give back to our communities through philanthropy and volunteerism. We give our best effort to our work, and we put people first. We’re looking for people who are determined to make life better for people around the world.

Eli Lilly and Company seeks a Structural Biologist (R5-R7) to support structure-based drug discovery (SBDD) projects focused on G protein-coupled receptors (GPCRs). Perform structure determination and drug design for GPCR and membrane protein targets as well as soluble protein targets. Apply biochemical, biophysical, and computational techniques to accelerate generation of high-quality reagents for X-ray crystallography and cryogenic electron microscopy (cryo-EM) studies. Determine structures and co-complex structures of protein targets for the design of small-molecule and antibody therapeutics. Develop integrative approaches to SBDD incorporating data and input from structural biology, biophysics, protein biochemistry, and medicinal chemistry teams.

Minimum Requirements:

1. Ph.D. in Structural Biology, Biophysics, Biochemistry, Chemistry, or a related field.
2. 2 years of academic or employment experience with GPCR biology, pharmacology, and structure-based research studies of GPCRs.
3. 2 years of experience with protein engineering, protein biochemistry, and protein structure determination by X-ray crystallography or cryo-EM.
4. 2 years of experience with construct design, molecular cloning, and protein expression and purification.
5. 2 years of experience with chromatographic methods for isolating recombinant proteins and HPLC/FPLC systems.
6. 2 years of experience with SDS-PAGE, Western blot, thermal shift assays, and ELISA.
7. 2 years of experience with computational tools for protein structure determination and analysis, including CCP4, Phenix, COOT, PyMol, and Chimera.

Job location: San Diego, CA. RATE OF PAY: $168,709.00 - $178,709.00 per year. To apply, please visit https://jobsearch.lilly.com/ and enter job requisition number R-84158 when prompted.

Lilly is dedicated to helping individuals with disabilities to actively engage in the workforce, ensuring equal opportunities when vying for positions. If you require accommodation to submit a resume for a position at Lilly, please complete the accommodation request form (https://careers.lilly.com/us/en/workplace-accommodation) for further assistance.

Lilly is proud to be an EEO Employer and does not discriminate on the basis of age, race, color, religion, gender identity, sex, gender expression, sexual orientation, genetic information, ancestry, national origin, protected veteran status, disability, or any other legally protected status.