Staff Scientist

US132 Guidehouse Digital, LLC; Tysons (VA); On-site; USD 110,000 - 150,000; Full time

Benefits offered by this job

Medical Insurance

Parental Leave

401(k) Retirement Plan

Job summary

Guidehouse is seeking a Staff Scientist to lead interdisciplinary research from bench to bedside with NHLBI. The role is full-time and on-site in Bethesda, MD, combining biochemical, molecular, cellular, and genetic approaches to study lysosome-related biology and disease.

The successful candidate will mentor lab members, present findings at scientific meetings, and collaborate across teams to advance translational research initiatives.

Qualifications

• PhD with minimum two years of postdoctoral research experience in molecular biology, cellular biology, biochemistry, or related field.
• Mastery of Zebrafish models including husbandry, genetic crossing, and genotyping protocols.
• Strong publication record across relevant disciplines.
• Experience working with animal models.
• Expertise in cellular biology and advanced microscopy imaging.

Responsibilities

• Provide laboratory leadership and support for interdisciplinary research.
• Collaborate across bench-to-bedside translational efforts with NHLBI.
• Train and mentor all laboratory members and staff.
• Present research findings at meetings and conferences.
• Characterize lysosome roles in physiological and pathological conditions.

Skills

Zebrafish models

Advanced microscopy

Publication record

Animal models

Molecular biology

Cell biology

Education

PhD

Job description

Job Family: Scientist Travel Required: None Clearance Required: Ability to Obtain Public Trust

What You Will Do:

We are currently searching for a Staff Scientist to provide laboratory leadership and support services to perform interdisciplinary and collaborative research from bench to beside with the National Heart, Lung, and Blood Institute (NHLBI). This is a full-time, on-site opportunity in Bethesda, MD. Combine biochemical, molecular, cellular, genetic, and quantitative approaches to investigate fundamental biological processes across a range of organisms, including fish, flies, mice, mammals, microbes, and viruses. Research how cells sense, respond, and adapt to a variety of stress conditions, including nutrient deprivation, organelle damage, and pathogen infection. Address how alterations in mTOR, TFEB, TFE3, and lysosomal function lead to human disease. Seek to identify potential sites for therapeutic intervention suitable for further evaluation in translational and clinical research efforts. Serve as laboratory lead contributing to training and mentoring of all laboratory members. Present research at meetings and conferences. Work in an interdisciplinary lab collaborating with others to advance research initiatives. Characterize the contribution of lysosomes to a variety of physiological processes, both in normal and pathological conditions.

What You Will Need:

• PhD with MINIMUM TWO (2) years of postdoctoral research experience in molecular biology, cellular biology, biochemistry, or related field.
• Must have a mastery of Zebrafish models with skills such as husbandry, genetic crossing, and genotyping protocols.
• Must have a strong publication record.
• Experience working with animal models.
• Expertise in cellular biology and advanced microscopy imaging.
• Must be able to obtain and maintain a Federal or DoD Public Trust.
• Candidates must receive approved adjudication of their Public Trust prior to onboarding with Guidehouse.
• Candidates with an active Public Trust or existing suitability are preferred.

What Would Be Nice To Have:

• Knowledge of organelle cell biology (lysosomes, autophagy, intracellular trafficking), and a commitment to conducting related high-quality research.
• Able to work independently and in a team setting.
• Excellent oral and written communication abilities.
• Outstanding interpersonal and time management skills.
• Demonstrated experience in staff training and mentoring.

What We Offer:

Guidehouse offers a comprehensive, total rewards package that includes competitive compensation and a flexible benefits package that reflects our commitment to creating a diverse and supportive workplace.

• Medical, Rx, Dental & Vision Insurance
• Personal and Family Sick Time & Company Paid Holidays
• Parental Leave
• 401(k) Retirement Plan
• Group Term Life and Travel Assistance
• Voluntary Life and AD&D Insurance
• Health Savings Account, Health Care & Dependent Care
• Flexible Spending Accounts
• Transit and Parking Commuter Benefits
• Short-Term & Long-Term Disability
• Tuition Reimbursement, Personal Development, Certifications & Learning Opportunities
• Employee Referral Program
• Corporate Sponsored Events & Community Outreach
• Care.com annual membership
• Employee Assistance Program
• Supplemental Benefits via Corestream (Critical Care, Hospital Indemnity, Accident Insurance, Legal Assistance and ID theft protection, etc.)
• Position may be eligible for a discretionary variable incentive bonus

About Guidehouse

Guidehouse is an Equal Opportunity Employer–Protected Veterans, Individuals with Disabilities or any other basis protected by law, ordinance, or regulation. Guidehouse will consider for employment qualified applicants with criminal histories in a manner consistent with the requirements of applicable law or ordinance including the Fair Chance Ordinance of Los Angeles and San Francisco.

If you have visited our website for information about employment opportunities, or to apply for a position, and you require an accommodation, please contact Guidehouse Recruiting at 1-571-633-1711 or via email at [e-mail]. All information you provide will be kept confidential and will be used only to the extent required to provide needed reasonable accommodation. All communication regarding recruitment for a Guidehouse position will be sent from Guidehouse email domains including @guidehouse.com or [e-mail]. Correspondence received by an applicant from any other domain should be considered unauthorized and will not be honored by Guidehouse.

Guidehouse does not accept unsolicited resumes through or from search firms or staffing agencies. All unsolicited resumes will be considered the property of Guidehouse and Guidehouse will not be obligated to pay a placement fee.

Guidehouse is a global AI-led professional services firm delivering advisory, technology, and managed services to the commercial and government sectors. With an integrated business technology approach, Guidehouse drives efficiency and resilience in the healthcare, financial services, energy, infrastructure, and national security markets. Built to help clients across industries outwit complexity, the firm brings together approximately 18,000 professionals to achieve lasting impact and shape a meaningful future. guidehouse.com