Staff Bioinformatics Engineer, Clinical Applications

Helix; California; À distance; USD 134 000 - 220 000; Plein temps

Avantages offerts par ce poste

Health Insurance

Paid Parental Leave

401(k) with employer matching

Well-Being Benefits

Flexible PTO

Remote options with home office

Résumé du poste

Helix is seeking Senior/Staff Bioinformatics Engineers for Clinical Applications to bridge genomic variants and clinical insights. You will productionize workflows, automate evidence gathering from ClinVar, gnomAD, and PubMed, and collaborate with scientists and product leaders to scale production systems for patient care.

You will guide AI coding agents, ensuring correctness and security, with Senior roles owning projects end to end and Staff roles shaping architectural direction across the

Qualifications

• Bachelor's degree in Science or related field with 7+ years (Senior) or 9+ years (Staff) of software development experience, or Master's/Ph.D. with 3+ years (Senior) or 5+ years (Staff).
• Production-quality Python and cloud platforms (AWS) experience required.
• Experience scaling AI/ML software and bioinformatics tools into production workflows.

Responsabilités

• Productionize curation workflows for variant classification using AI/ML approaches.
• Automate evidence integration from ClinVar, gnomAD, and PubMed.
• Collaborate with scientists, product, and clinical teams to meet requirements.
• Direct AI coding agents to accelerate curation pipelines with secure, scalable design.
• Senior: own projects end to end and make architectural trade-offs.

Connaissances

Python

AI/ML software

Cloud platforms

Collaboration with scientists

Formation

Bachelor's degree in Science or related field

Master's or Ph.D. with 3+ years (Senior) or 5+ years (Staff)

Outils

LangChain

LangGraph

Relational databases

Description du poste

Who We Are & What We Do

At Helix, our mission is simple: to help everyone improve their lives through their DNA.

What is special about this role?

You’ll bridge the gap between genomic variants and the clinical answers that help patients act on their DNA. You’ll partner with scientists and product leaders to turn promising prototypes into production systems that scale. Your code will power how Helix automates gene and variant curation for real patients.

We have openings for both Senior and Staff level Engineers. You may apply at either level, and we’ll consider your experience, qualifications and demonstrated scope when determining the right level.

As a Senior/Staff Bioinformatics Engineer, Clinical Applications, You Will

• Productionize curation workflows that support both classical and modern AI/ML approaches to variant classification.
• Automate evidence integration from sources such as ClinVar, gnomAD, and PubMed.
• Collaborate closely with scientists, product, and clinical stakeholders to ensure software solutions meet scientific and product requirements.
• Direct AI coding agents to accelerate development of curation pipelines, applying engineering judgment to validate correctness, security, and architectural fit before deployment.
• At Senior level, own defined projects end to end, make technical decisions within agreed priorities and architecture, and raise trade-offs that affect broader systems.
• At Staff level, independently frame ambiguous problems, set technical direction, and make consequential architecture and prioritisation decisions across the product area.

About You

• Bachelor's degree in Science or related field with 7+ years (Senior) or 9+ years (Staff) of professional software development experience. Or, a Master's or Ph.D. with 3+ years (Senior) or 5+ years (Staff) of professional software development experience.
• Advanced proficiency in production-quality Python, relational databases, and cloud platforms such as AWS.
• Experience productionizing and scaling AI/ML software, especially agentic systems built with frameworks such as LangChain or LangGraph.
• Experience collaborating with scientists to integrate bioinformatics/NGS tools and databases into production workflows.
• Strong judgment evaluating AI-generated code and pipeline logic for correctness, security, and maintainability before it reaches production.

Pluses

• Experience in clinical genomics, such as ACMG guidelines, clinical diagnostics, or Human Phenotype Ontology (HPO) terms.
• Experience developing regulated software, such as software as a medical device.
• At Staff level, the role may have the opportunity to take on people leadership responsibilities. Experience mentoring or managing others, or an interest in developing as a people leader, is a plus.

Expected Interview Process

• Recruiter Screen 2) Manager Screen/Tech Screen 3) Onsite 4) Offer

Expected Pay For This Role

There are 3 distinct parts to your Helix offer: 1) Base Salary 2) Annual Bonus 3) Equity

• Expected Helix Base: $161,500 - $219,625 (Staff)
• Expected Helix Base: 134,000 - $179,000 (Senior)
• Expected Helix Discretionary Annual Bonus: 15% (Staff)/ 10% (Senior) of your annual salary
• Equity: We offer generous equity at Helix. If you receive a Helix offer your recruiter will book dedicated time with you to educate you on our equity model.

Aside from working alongside brilliant, dedicated, passionate, down-to-earth, curious, warm, and thoughtful people, we also provide great benefits:

• Comprehensive Health Insurance with Date of Hire eligibility
  • Above average employer paid premium coverage
• 12 weeks Helix Paid Parental Leave option
• 401(k) with employer matching of up to 3% and 100% Vesting on the Date of Hire
• Comprehensive Well-Being Benefits
• Flexible PTO
• Remote options for many roles and a home office stipend

What To Expect During Your First 90 Days

• First 30 days: you’ll spend time learning the Helix way, completing training and onboarding for your roles, and getting introduced to your team and relevant stakeholders. You’ll also gain a deeper understanding of our customers, our products, the impact we make in the lives of our communities, and how to thrive at Helix through participation in Helix U.
• Day 30 - 60: you’ll spend time contributing to projects, deeply familiarizing yourself with team and company processes, and developing a deeper understanding of Helix’s products, services and capabilities.
• Day 60 - 90: you’ll build your OKRs with your manager, start to take ownership of projects and initiatives on your team, and begin to demonstrate your impact on the Helix mission.

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Helix is proud to be an equal opportunity employer, and committed to providing employment opportunities regardless of race, religious creed, color, national origin, ancestry, physical disability, mental disability, medical condition, genetic information, marital status, sex, gender, gender identity, gender expression, pregnancy, childbirth and breastfeeding, age, sexual orientation, military or veteran status, or any other protected classification, in accordance with applicable federal, state, and local laws.