Sr. Scientist, Discovery DMPK

Arrowhead Pharmaceuticals; Madison (WI); On-site; USD 100,000 - 130,000; Full time

Job summary

Join a forward-thinking biopharmaceutical company as a Scientist in the discovery DMPK group. This role is pivotal in understanding the ADME of innovative RNAi therapeutics targeting genetic diseases. Collaborate with a dynamic team to perform advanced quantitation methods, cell type separation, and interpret results that drive drug delivery success. If you are a motivated individual with a PhD in pharmacology or biological sciences, and a passion for innovation, this opportunity offers a chance to make a significant impact in the field. Embrace a collaborative environment where your contributions can lead to groundbreaking therapies for patients in need.

Qualifications

• PhD in pharmacology or biological sciences is essential.
• Hands-on experience with quantitation methods from biological matrices.

Responsibilities

• Draft and execute ADME study requests and assays.
• Interpret results to facilitate drug delivery and present data.

Skills

Problem Solving

Communication Skills

Self-Motivation

Innovation

Education

PhD in Pharmacology

PhD in Biological Sciences

Tools

LC-HRMS

LC-UV

qPCR

Job description

Arrowhead Pharmaceuticals, Inc. (Nasdaq: ARWR) is a clinical stage biopharmaceutical company that develops medicines that treat intractable diseases by silencing the genes that cause them. Using a broad portfolio of RNA chemistries and efficient modes of delivery, Arrowhead therapies trigger the RNA interference mechanism to induce rapid, deep, and durable knockdown of target genes. RNA interference, or RNAi, is a mechanism present in living cells that inhibits the expression of a specific gene, thereby affecting the production of a specific protein. Arrowhead’s RNAi-based therapeutics leverage this natural pathway of gene silencing.

Arrowhead is focused on developing innovative drugs for diseases with a genetic basis, typically characterized by the overproduction of one or more proteins that are involved with disease. The depth and versatility of our RNAi technologies enables us to potentially address conditions in virtually any therapeutic area and pursue disease targets that are not otherwise addressable by small molecules and biologics. Arrowhead is leading the field in bringing the promise of RNAi to address diseases outside of the liver, and our clinical pipeline includes disease targets in the liver and lung with a promising pipeline of preclinical candidates.

Arrowhead’s corporate headquarters is in Pasadena, CA with research and development teams in Madison, WI and San Diego, CA. Our employees are nimble, science-driven innovators who are collaborating to bring new therapies to patients in need.

The Position

Arrowhead Pharmaceuticals is seeking a Scientist to join our discovery DMPK group in the Chemistry Department. The successful candidate will play a critical role in understanding the ADME of Arrowhead’s TRIM platforms targeting new cell types.

Responsibilities:

• Draft ADME study requests
• Perform cell type separation, enrichment and depletion as needed
• Perform LC-HRMS, LC-UV or qPCR based quantitation
• Interpret ADME results to facilitate drug delivery
• Act as discovery DMPK lead and present data in cross-functional meetings
• Document experimental procedure and results accurately
• Execute all assays in a timely manner to meet deadlines
• Be able to work in a highly dynamic and fast-moving environment; meet project goal within deadline

Requirements:

• PhD in pharmacology or biological sciences
• Hands-on experience with one of the quantitation methods listed above from biological matrices
• Hands-on experience with cell separation, enrichment or depletion
• Demonstrated innovation, creativity and resilience in problem solving
• Excellent oral and written communication skills and collaborative personality
• Highly self-motivated with a can-do attitude

Preferred:

• Extensive experience in cell separation, enrichment and depletion
• Demonstrated practical understanding of pharmacokinetics and pharmacodynamics

Wisconsin pay range: $100,000—$130,000 USD

Arrowhead provides competitive salaries and an excellent benefit package.

All applicants must have authorization to work in the US for a company.

Seniority level

Mid-Senior level

Employment type

Full-time

Job function

Research, Analyst, and Information Technology