Sr. Scientist, Discovery DMPK

Arrowhead Pharmaceuticals, Inc; Madison (WI); On-site; USD 70,000 - 110,000; Full time

Job summary

Join a pioneering biopharmaceutical company at the forefront of RNA interference technology, where your expertise as a Scientist will contribute to groundbreaking therapies targeting intractable diseases. In this dynamic role within the discovery DMPK group, you will engage in critical research activities, including drafting ADME study requests and performing advanced quantitation methods. Collaborate with a team of innovative scientists dedicated to transforming the treatment landscape for genetic diseases. This is a unique opportunity to make a significant impact in a fast-paced environment, where your skills and creativity will be valued and rewarded.

Benefits

Competitive salary

Excellent benefit package

Qualifications

• PhD in pharmacology or biological sciences is required.
• Hands-on experience with quantitation methods from biological matrices.

Responsibilities

• Draft ADME study requests and perform cell type separation.
• Interpret ADME results and act as discovery DMPK lead.

Skills

ADME study drafting

Cell type separation

Quantitation methods (LC-HRMS, LC-UV, qPCR)

Problem solving

Communication skills

Education

PhD in pharmacology or biological sciences

Tools

LC-HRMS

LC-UV

qPCR

Job description

Arrowhead Pharmaceuticals, Inc. (Nasdaq: ARWR) is a clinical stage biopharmaceutical company that develops medicines that treat intractable diseases by silencing the genes that cause them. Using a broad portfolio of RNA chemistries and efficient modes of delivery, Arrowhead therapies trigger the RNA interference mechanism to induce rapid, deep, and durable knockdown of target genes. RNA interference, or RNAi, is a mechanism present in living cells that inhibits the expression of a specific gene, thereby affecting the production of a specific protein. Arrowhead’s RNAi-based therapeutics leverage this natural pathway of gene silencing.

Arrowhead is focused on developing innovative drugs for diseases with a genetic basis, typically characterized by the overproduction of one or more proteins that are involved with disease. The depth and versatility of our RNAi technologies enables us to potentially address conditions in virtually any therapeutic area and pursue disease targets that are not otherwise addressable by small molecules and biologics. Arrowhead is leading the field in bringing the promise of RNAi to address diseases outside of the liver, and our clinical pipeline includes disease targets in the liver and lung with a promising pipeline of preclinical candidates.

Arrowhead’s corporate headquarters is in Pasadena, CA with research and development teams in Madison, WI and San Diego, CA. Our employees are nimble, science-driven innovators who are collaborating to bring new therapies to patients in need.

The Position

Arrowhead Pharmaceuticals is seeking a Scientist to join our discovery DMPK group in the Chemistry Department. The successful candidate will play a critical role in understanding the ADME of Arrowhead’s TRIM platforms targeting new cell types.

Responsibilities:

• Draft ADME study requests
• Perform cell type separation, enrichment and depletion as needed
• Perform LC-HRMS, LC-UV or qPCR based quantitation
• Interpret ADME results to facilitate drug delivery
• Act as discovery DMPK lead and present data in cross-functional meetings
• Document experimental procedure and results accurately
• Execute all assays in a timely manner to meet deadlines
• Be able to work in a highly dynamic and fast-moving environment; meet project goal within deadline

Requirements:

• PhD in pharmacology or biological sciences
• Hands-on experience with one of the quantitation method listed above from biological matrices
• Hands-on experience with cell separation, enrichment or depletion
• Demonstrated innovation, creativity and resilience in problem solving
• Excellent oral and written communication skills and collaborative personality
• Highly self-motivated with a can-do attitude

Preferred:

• Extensive experience in cell separation, enrichment and depletion
• Demonstrated practical understanding of pharmacokinetics and pharmacodynamics

Arrowhead provides competitive salaries and an excellent benefit package.

All applicants must have authorization to work in the US for a company.