Sr. Scientist – Cell Based Assay, Bioanalytical Lab

NorthEast BioAnalytical Laboratories LLC; Hamden, Northern (CT, KY); Hybrid; USD 110,000 - 190,000; Full time

Job summary

NorthEast BioLab in Hamden, CT, is seeking a Sr. Scientist – Cell Based Assay to lead development of cell-based bioanalytical assays. You will drive innovative R&D projects, transfer methods, and generate high-quality data while ensuring GLP-like rigor.

The role involves collaboration with a dynamic scientific team and opportunities for leadership within the lab. The candidate will design and optimize assays, manage project lifecycles, and interact with sponsors.

Qualifications

• Doctorate or Master’s degree in biochemistry, molecular biology, cell biology, or related field.
• Hands-on experience in cell-based assays.
• Proficiency with flow cytometry and molecular assays.
• Experience with BSL-1/BSL-2 systems and relevant assays.
• Familiarity with assay development, validation, and data analysis.
• Strong analytical and problem-solving capabilities.

Responsibilities

• Pioneer design and refinement of cell-based assays with scientific rigor.
• Lead assay transfer, training, and troubleshooting within the team.
• Conduct full-cycle bioanalytical development from feasibility to validation.
• Interpret data, shape procedures, and communicate results to stakeholders.
• Maintain reagent, assay, equipment, and personnel records per SOPs.
• Manage lifecycle of cell-based assay projects to meet objectives.
• Enhance sponsor engagement and contribute to proposals.

Skills

Cell culture

Cytotoxicity

Immunogenicity

Neutralizing antibodies

Biomarker identification

ADME/DMPK

Potency evaluations

Flow cytometry

qPCR

ddPCR

ELISA

MSD

FlowJo

Softmax Pro

GraphPad Prism

Education

Doctorate or Master’s in biochemistry / molecular biology / cell biology

Tools

FlowJo

Softmax Pro

GraphPad Prism

Job description

• Sr. Scientist - Cell Based Assay, Bioanalytical Lab

Sr. Scientist – Cell Based Assay, Bioanalytical Lab – Hamden, CT, USA

Company Overview
Embark on an extraordinary career opportunity with NorthEast BioLab. As an independent US-based lab services CRO, we pride ourselves on our commitment to Good Laboratory Practice (GLP) and clinical bioanalytical services.

• Dedicated to Innovation: Our two-decade journey of innovation positions us as a key player at the helm of bioanalytical advancements.
• Work: At NorthEast BioLab, your contributions will be pivotal in shaping groundbreaking therapeutics that transform lives.
• Renowned Expertise: Work alongside a team of respected scientists known for their proficiency in the intricacies of assay development, from inception to validation.

Work Location

The role is based on-site, providing the opportunity to engage directly with advanced laboratory equipment and collaborate within a scientific community

Role Overview

• Drive Innovative Research: Command the lab in groundbreaking R&D projects, becoming an integral part of our quest for scientific discovery.
• Generate Impactful Data: Produce pivotal bioanalytical data, maintaining the utmost standards of compliance and integrity.
• Forge Collaborative Success: Unite with our dynamic teams to develop client‑centric, cutting‑edge assay solutions.
• Thrive in Our Community: Be part of a culture that nurtures your professional ambitions and supports your growth at every turn.
• Accelerate Your Career: Propel your career forward in an energetic and fast‑paced environment that celebrates your innovation and hard work.
• Pave Path to Leadership: Navigate transparent opportunities for advancement, whether you aim to lead within our Technical Development team or explore other avenues.

Responsibilities

• Pioneer Assay Design: Drive the creation and refinement of cell‑based assays in relevant biological systems with appropriate scientific rigor.
• Champion Assay Transfer: Lead method tech transfers, becoming the go‑to person for training and troubleshooting within our vibrant scientific community.
• Perform Bioanalytical Development: Conduct full‑cycle assays, from initial feasibility evaluation to FFP qualification or GLP validation to sample analysis
• Lead Data Interpretation And Reporting: Transform raw data into valuable insights, shaping test procedures and submissions, effectively communicating results to stakeholders.
• Oversee Assay Documentation: Maintain impeccable reagent, assay, personnel, equipment records, etc. aligning with our SOPs and regulatory requirements.
• Manage Assay Lifecycle: Evaluate and manage the full lifecycle of cell‑based assay projects, ensuring they meet scientific, regulatory, and business objectives.
• Enhance Sponsor Engagement: Apply your scientific acumen to elevate client interactions and improve SOW/proposals.

Qualifications

• Educational Background: A Doctorate or Master’s degree in biochemistry, molecular biology, cell biology, or a related field, with significant hands‑on experience in cell‑based assays.
• Assay Expertise: Proficiency in cell culture, cytotoxicity, immunogenicity, neutralizing antibody assays, biomarker identification, ADME/DMPK studies, and potency evaluations.
• Virology Skills: Experience with BSL-1 and BSL-2 viral systems, including AAV, RCL, and RCR.
• Technical Proficiency: Familiarity with assay technologies such as flow cytometry, qPCR, ddPCR, ELISA, and MSD.
• Software Mastery: Competence in bioanalysis software including FlowJo, Softmax Pro, and GraphPad Prism for data management and analysis.
• Research Commitment: Dedication to scientific research and problem‑solving in the face of challenges.
• Analytical and Communication Skills: Strong critical thinking abilities and excellent communication skills, with the capacity to convey complex scientific information effectively.