Sr. Scientist

Legend Biotech USA; Philadelphia (Philadelphia County); On-site; USD 140,000 - 190,000; Full time

Job summary

Legend Biotech USA seeks a Sr. Scientist to join the Philadelphia R&D team, focusing on in-vivo CAR therapy development.

You will design experiments, optimize cell therapies, and evaluate viral vectors using in vitro and in vivo assays across solid tumor models. The role requires a PhD in Immunology and at least 4 years of experience in cell and gene therapy, with strong flow cytometry and cytokine assay skills.

Qualifications

• PhD in Immunology or related discipline.
• 4 years of experience in cell and gene therapy; in vivo CAR-T experience preferred.
• Extensive experience in immune cell analytics and assays (flow cytometry, cytotoxicity, cytokine ELISA/MSD).
• Experience with lentivirus particle characterization and quantification (VCN) and flow-based assays.
• Experience with solid tumor models and in vivo cell delivery is a plus.

Responsibilities

• Lead, design and optimize research exploring next generation cell therapies using in-vivo CAR-T.
• Dissect published literature to enable novel in-vivo cell therapy solutions.
• Isolate immune cells from leukopak or blood and evaluate in-vivo CAR virus with in-vitro and in-vivo assays.
• Perform solid tumor research using cell biology techniques (culture, transfection, FACS, functional assays).
• Package and titer engineered viruses; characterize virus particles and measure transduction rate.
• Generate and maintain data with ELN; present results to diverse audiences.
• Ensure compliance with GLP and EHS protocols.

Skills

Immunology

In vivo CAR-T

Flow cytometry

Cytokine assays

Lentivirus production

Virus titering

Molecular biology

Cell therapy

Data management

Education

PhD in Immunology

Tools

ELN (electronic lab notebook)

PCR-based assays

FACS analysis

Job description

Legend Biotech is seeking a Sr. Scientist as part of the Research & Development team based in Philadelphia, Pennsylvania.

Role Overview

We are seeking an initiative-taking and creative scientist to grow our pipeline efforts. The candidate will be part of Legend Biotech, a leading cell therapy company with a commercial CAR drug product CARVYKTI and an attractive pipeline portfolio. The candidate will be an integral part of our Philadelphia R&D team, whose aim is to research, develop and advance the next generation of cell therapies using innovative in vivo delivery technologies and create novel CAR therapy to treat a wide range of cancer and autoimmune disease indications. This position will focus on in-vivo CAR. The position requires enthusiasm, passion, outstanding skills in the art, diligence, and a desire to create new medicines for patients.

Key Responsibilities

• Lead, design and optimize research with aims of exploring next generation cell therapies using in-vivo CAR-T.
• Contribute to project creation and formation through dissection of published literature to find novel solutions to in-vivo cell therapy problems.
• Isolate immune cells from leukopak or blood of healthy donors or patients and execute the evaluation of in-vivo CAR virus using a battery of in-vitro assays and in-vivo mice models.
• Perform treatment of solid tumor research requiring cell biology techniques including cell culture, transfection, FACS, and cell-based functional assays.
• Package and titer engineered viruses to infect immune cells in vitro and in vivo; Characterize virus particles with protein and PCR based assays; Measure transduction rate using flow and VCN analysis.
• Generate, manage, evaluate, and maintain critical data in a highly organized manner, including the use of ELN.
• Deliver result to meet timeline with accountability through presentation to a wide range of audiences of internal group meetings and other forums.
• Maintain compliance with GLP and EHS protocols.

Requirements

• PhD in Immunology or related discipline.
• 4 years of experience in the field of cell and gene therapy, in vivo CAR-T experience preferred.
• Extensive experience in immune cell-based analytics and assay development including but not limited to advanced multi-parameter flow-cytometry, immunogenicity assay such as cytotoxicity assay, cytokine release ELISA/MSD multiplex assays.
• Experience with lentivirus particle characterization and quantification using molecular (VCN) and flow-based assays.
• Experience with solid tumor models and in vivo cell-specific gene delivery is a plus.
• Track record of productivity is evidenced by publications or patents.
• Be able to work independently to plan and timely execute research projects
• Deep knowledge of immunology and immunotherapy; a deep understanding of solid tumor models is preferred
• Proficient in advanced gene delivery methods using LVV, VLP or LNP technologies
• Strong experience with lentivirus production, tittering and transduction.
• Working molecular biology and cellular biology knowledge in design and evaluation of modified viral vectors
• Strong multitasking, problem-solving and collaborative skills
• Excellent verbal and written communication skills

Legend Biotech is a global biotechnology company dedicated to treating, and one day curing, life-threatening diseases. Headquartered in Somerset, New Jersey, we are developing advanced cell therapies across a diverse array of technology platforms, including autologous and allogenic chimeric antigen receptor T-cell, T-cell receptor (TCR-T), and natural killer (NK) cell-based immunotherapy. From our three R&D sites around the world, we apply these innovative technologies to pursue the discovery of safe, efficacious and cutting-edge therapeutics for patients worldwide.

Legend Biotech entered into a global collaboration agreement with Janssen, one of the pharmaceutical companies of Johnson & Johnson, to jointly develop and commercialize ciltacabtagene autolecuel (cilta-cel). Our strategic partnership is designed to combine the strengths and expertise of both companies to advance the promise of an immunotherapy in the treatment of multiple myeloma.

Please note: These benefits are offered exclusively to permanent full-time employees. Contractors are not eligible for benefits through Legend Biotech.

Work Authorization & Employment Eligibility

Applicants must be authorized to work in the United States. As part of our commitment to maintaining a lawful workforce and ensuring compliance with federal employment regulations, we participate in the E-Verify program. If you are selected for employment, you will be required to complete the Form I-9 process, and your employment eligibility will be verified through E-Verify in accordance with applicable federal law. We are committed to providing a fair, transparent, and welcoming hiring experience for all candidates.

EEO Statement

It is the policy of Legend Biotech to provide equal employment opportunities without regard to actual or perceived race, color, creed, religion, national origin, ancestry, citizenship status, age, sex or gender (including pregnancy, childbirth, related medical conditions and lactation), gender identity or gender expression (including transgender status), sexual orientation, marital status, military service and veteran status, disability, genetic information, or any other protected characteristic under applicable federal, state or local laws or ordinances.

Employment is at-will and may be terminated at any time with or without cause or notice by the employee or the company.

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