Scientist

BioSpace; Philadelphia (Philadelphia County); On-site; USD 127,000 - 147,000; Full time

Benefits offered by this job

Medical, dental, and vision insurance

401(k) with company match

Eight weeks of paid parental leave

Paid time off and holidays

Job summary

Legend Biotech in Philadelphia, PA is seeking a highly motivated Scientist to join our growing In Vivo CAR‑T Cell Therapy team. You will contribute to the development of our in vivo CAR‑T platform and pipeline by applying expertise in cellular immunotherapy, virology, and immunology.

This role supports the Early Career Leadership Program and the R&D Hi‑Po Leadership Development Program, offering mentorship, cross‑functional exposure, and opportunities to influence strategy and pipeline

Qualifications

• PhD in Immunology or related field required.
• 3+ years in cell and gene therapy research; CAR‑T experience highly preferred.
• Strong hands-on experience with cellular immunology, viral vectors and functional assays.
• Proven scientific productivity via publications or patents.
• Excellent communication and collaboration skills.

Responsibilities

• Design and execute research projects to advance cell and gene therapy platforms and pipeline.
• Develop and optimize assays including lentiviral vector production and titration, flow cytometry, ELISA, and PCR‑based analyses.
• Conduct in vitro and in vivo studies to evaluate potency, function, and safety of candidates.
• Collaborate with cross‑functional teams to ensure robust, data‑driven conclusions.
• Document results clearly and maintain data integrity.
• Contribute to scientific strategy and pipeline advancement.

Skills

CAR‑T cell therapy

Cellular immunology

Viral vector technologies

Experimental design

Education

PhD in Immunology

Tools

Flow cytometry

PCR

Lentiviral vector production

ELISA

Incucyte

Job description

Legend Biotech is a global biotechnology company dedicated to treating and, one day, curing life‑threatening diseases. Headquartered in Bridgewater, New Jersey, we are advancing the next generation of cell therapy through a portfolio of innovative technologies, including autologous, allogeneic, and in vivo cell therapy approaches. Our research spans chimeric antigen receptor T‑cell (CAR‑T), T‑cell receptor (TCR‑T), natural killer (NK) cell‑based therapies, and other emerging platforms designed to transform the treatment of serious diseases. From our global network of research and development sites, we are committed to discovering and developing safe, effective, and cutting‑edge therapies for patients worldwide.

Legend Biotech entered into a global collaboration agreement with Johnson & Johnson to jointly develop and commercialize CARVYKTI® (ciltacabtagene autoleucel; cilta‑cel). Through this strategic partnership, we combine complementary expertise and capabilities to advance innovative immunotherapies for patients living with multiple myeloma.

Legend Biotech is seeking a Scientist as part of the R&D Leadership Development Program based in Philadelphia, PA.

Role Overview

The Early Career Leadership Program at Legend Biotech is a strategic, enterprise‑focused development experience designed to accelerate the growth of high‑potential professionals early in their careers. Rooted in our commitment to cultivating enterprise‑minded, value‑driven leaders, this program provides structured rotational exposure, executive mentorship, and real‑time business impact across scientific, operational, and corporate functions.

The R&D Hi‑Po Leadership Development Program is a project‑based, enterprise leadership accelerator designed for high‑potential PhD graduates who aspire to shape the future of cell and gene therapy.

This immersive experience is built to cultivate scientific leaders capable of translating discoveries into development, advancing complex pipeline programs, and influencing cross‑functional strategy. Participants will gain enterprise exposure, executive mentorship, and access to a formal Annual Leadership Development Series focused on strategic thinking, regulatory and clinical acumen, and senior leadership readiness. Join us in advancing the frontiers of cell and gene therapy—where your discoveries can redefine treatment paradigms and transform patient outcomes worldwide.

We are seeking a highly motivated Scientist to join our growing In Vivo CAR‑T Cell Therapy team. The successful candidate will contribute to the development of our in vivo CAR‑T platform and pipeline by leveraging expertise in cellular immunotherapy, virology, and immunology. This role requires scientific excellence, strong collaboration skills, and the ability to drive projects in a fast‑paced environment.

Join us in redefining what’s possible and build a career where your growth and patient impact go hand in hand.

Key Responsibilities

• Design and execute research projects to drive innovation of cell and gene therapy platforms and advance pipeline development.
• Develop and optimize assays, including but not limited to lentiviral vector production and titration, advanced multi‑parameter flow cytometry, Incucyte, ELISA, cytotoxicity assays, and PCR‑based analyses.
• Conduct in vitro and in vivo studies to evaluate potency, function, and safety of drug candidates.
• Collaborate closely with cross‑functional teams to evaluate novel designs and generate robust, reproducible, and data‑driven conclusions.
• Analyze, interpret, and document experimental results in a timely and highly organized manner, maintaining accurate scientific records and ensuring data integrity.
• Contribute to scientific strategy, experimental planning, and technology innovation to support pipeline advancement.

Requirements

• PhD in Immunology or a related discipline.
• Minimum of 3 years of experience in cell and gene therapy research, with experience in CAR‑T cell therapy strongly preferred.
• Strong hands‑on experience with cellular immunology, viral vector technologies, and functional assay development.
• Demonstrated scientific productivity through publications, patents, or equivalent achievements.
• Strong experimental design, data analysis, troubleshooting, and problem‑solving skills.
• Excellent verbal and written communication skills, with the ability to effectively present complex scientific concepts to diverse audiences.
• Passion for advancing next‑generation cell and gene therapies.
• Strong sense of scientific ownership, accountability, and attention to detail.
• Commitment to continuous learning and staying current with emerging scientific and industry developments.
• Strong team‑oriented mindset with a willingness to mentor and support colleagues.
• Ability to thrive in a dynamic, fast‑paced, and highly collaborative environment.

The base pay range below is what Legend Biotech USA Inc. reasonably expects to offer at the time of posting. Actual compensation may vary based on experience, skills, qualifications, and geographic location. The company reserves the right to modify this range as needed and in accordance with applicable laws.

Other Types of Pay: Performance‑based bonus and/or equity is available to employees in eligible roles.

Benefits and Paid Time Off: Medical, dental, and vision insurance as well as a 401(k) retirement plan with a company match that vests fully on day one. We offer eight (8) weeks of paid parental leave after just three (3) months of employment, and a paid time off policy that includes vacation time, personal time, sick time, floating holidays, and eleven (11) company holidays. Additional voluntary benefits include flexible spending and health savings accounts, life and AD&D insurance, short‑ and long‑term disability coverage, legal assistance, and supplemental plans such as pet, critical illness, accident, and hospital indemnity insurance. We also provide voluntary commuter benefits, family planning and care resources, well‑being initiatives, and peer‑to‑peer recognition programs; demonstrating our ongoing commitment to building a culture where our people feel empowered, supported, and inspired to do their best work.

Pay Range (Base Pay)

$127,313 - $147,099 USD

Please note: These benefits are offered exclusively to permanent full‑time employees. Contractors are not eligible for benefits through Legend Biotech.

Work Authorization & Employment Eligibility

Applicants must be authorized to work in the United States. As part of our commitment to maintaining a lawful workforce and ensuring compliance with federal employment regulations, we participate in the E‑Verify program. If you are selected for employment, you will be required to complete the Form I-9 process, and your employment eligibility will be verified through E‑Verify in accordance with applicable federal law. We are committed to providing a fair, transparent, and welcoming hiring experience for all candidates.

EEO Statement

It is the policy of Legend Biotech to provide equal employment opportunities without regard to actual or perceived race, color, creed, religion, national origin, ancestry, citizenship status, age, sex or gender (including pregnancy, childbirth, related medical conditions and lactation), gender identity or gender expression (including transgender status), sexual orientation, marital status, military service and veteran status, disability, genetic information, or any other protected characteristic under applicable federal, state or local laws or ordinances.

Employment is at‑will and may be terminated at any time with or without cause or notice by the employee or the company.

For information related to our privacy notice, please review: Legend Biotech Privacy Notice.