Scientist

Legend Biotech; Philadelphia (Philadelphia County); On-site; USD 96,267 - 126,351; Full time

Benefits offered by this job

Medical insurance

Dental insurance

Vision insurance

401(k)

Job summary

Legend Biotech is seeking an initiative-taking scientist for the Philadelphia R&D team to advance the next generation of in‑vivo CAR therapies. You will work within a collaborative group focused on immune cell biology and cancer indications, advancing discovery programs with innovative delivery technologies.

You will apply state‑of‑the‑art immunology knowledge, lead experiments, and deliver timely results to cross‑functional teams, while maintaining GLP/EHS standards.

Qualifications

• PhD in Immunology or related discipline.
• 2 years of experience in cell and gene therapy, in vivo CAR‑T experience preferred.
• Extensive experience with multi‑parameter flow cytometry and immunoassays such as cytotoxicity ELISA/MSD multiplex assays.
• Experience with lentivirus particle characterization and quantification using molecular (VCN) and flow‑based assays.

Responsibilities

• Design and optimize research with aims of exploring next generation cell therapies using in‑vivo CAR‑T.
• Contribute to project creation and formation through literature review to find novel solutions.
• Isolate immune cells from leukopak or blood and evaluate in‑vivo CAR virus using in‑vitro assays and in‑vivo models.
• Perform solid tumor research using cell biology techniques including culture, transfection, FACS, and functional assays.
• Package and titer engineered viruses to infect immune cells in vitro and in vivo; characterize virus particles.
• Maintain data in an organized ELN and deliver results to internal audiences.

Skills

Flow cytometry

Independent work

Communication

Collaboration

Immunology knowledge

Education

PhD in Immunology

Tools

Lentivirus production

In vivo models

PCR/QPCR

ELISA

T-cell biology

Job description

Legend Biotech is a global biotechnology company dedicated to treating, and one day curing, life‑threatening diseases. Headquartered in Somerset, New Jersey, we are developing advanced cell therapies across a diverse array of technology platforms, including autologous and allogenic chimeric antigen receptor T‑cell, T‑cell receptor (TCR‑T), and natural killer (NK) cell‑based immunotherapy. From our three R&D sites around the world, we apply these innovative technologies to pursue the discovery of safe, efficacious and cutting‑edge therapeutics for patients worldwide.

Legend Biotech entered into a global collaboration agreement with Janssen, one of the pharmaceutical companies of Johnson & Johnson, to jointly develop and commercialize ciltacabtagene autolecuel (cilta‑cel). Our strategic partnership is designed to combine the strengths and expertise of both companies to advance the promise of an immunotherapy in the treatment of multiple myeloma.

Role Overview

We are seeking an initiative‑taking and creative scientist to grow our pipeline efforts. The candidate will be part of Legend Biotech, a leading cell therapy company with a commercial CAR drug product CARVYKTI and an attractive pipeline portfolio. The candidate will be an integral part of our Philadelphia R&D team, whose aim is to research, develop and advance the next generation of cell therapies using innovative in‑vivo delivery technologies and create novel CAR therapy to treat a wide range of cancer and autoimmune disease indications. This position will focus on in‑vivo CAR. The position requires enthusiasm, passion, outstanding skills in the art, diligence, and a desire to create new medicines for patients.

Expertise in immunology and/or oncology is required. The ideal candidate will be a highly motivated individual who enjoys fast paced biotech environment. You thrive in a collaborative work environment. Knowledge of state‑of‑the‑art immunotherapy and its applications. As part of the Legend Biotech R&D team and under minimal supervision, you will be responsible for timely execution and delivery of projects in our discovery pipeline.

Key Responsibilities

• Design and optimize research with aims of exploring next generation cell therapies using in‑vivo CAR‑T.
• Contribute to project creation and formation through dissection of published literature to find novel solutions to in‑vivo cell therapy problems.
• Isolate immune cells from leukopak or blood of healthy donors or patients and execute the evaluation of in‑vivo CAR virus using a battery of in‑vitro assays and in‑vivo mice models.
• Perform treatment of solid tumor research requiring cell biology techniques including cell culture, transfection, FACS, and cell‑based functional assays.
• Package and titer engineered viruses to infect immune cells in vitro and in vivo; characterize virus particles with protein and PCR based assays; measure transduction rate using flow and VCN analysis.
• Generate, manage, evaluate, and maintain critical data in a highly organized manner, including the use of ELN.
• Deliver results to meet timeline with accountability through presentation to a wide range of audiences of internal group meetings and other forums.
• Maintain compliance with GLP and EHS protocols.

Requirements

• PhD in Immunology or related discipline.
• 2 years of experience in the field of cell and gene therapy, in vivo CAR‑T experience preferred.
• Extensive experience in immune cell‑based analytics and assay development including but not limited to advanced multi‑parameter flow‑cytometry, immunogenicity assay such as cytotoxicity assay, cytokine release ELISA/MSD multiplex assays.
• Experience with lentivirus particle characterization and quantification using molecular (VCN) and flow‑based assays.
• Experience with solid tumor models and in vivo cell‑specific gene delivery is a plus.
• Track record of productivity is evidenced by publications or patents.
• Be able to work independently to plan and timely execute research projects.
• Deep knowledge of immunology and immunotherapy; a deep understanding of solid tumor models is preferred.
• Proficient in advanced gene delivery methods using LVV, VLP or LNP technologies.
• Strong experience with lentivirus production, titering and transduction.
• Working molecular biology and cellular biology knowledge in design and evaluation of modified viral vectors.
• Strong multitasking, problem‑solving and collaborative skills.
• Excellent verbal and written communication skills.

Benefits and Paid Time Off

The base pay range below is what Legend Biotech USA Inc. reasonably expects to offer at the time of posting. Actual compensation may vary based on experience, skills, qualifications, and geographic location. The company reserves the right to modify this range as needed and in accordance with applicable laws. Other types of pay: performance‑based bonus and/or equity is available to employees in eligible roles.

Medical, dental, and vision insurance as well as a 401(k) retirement plan with a company match that vests fully on day one. We offer eight (8) weeks of paid parental leave after just three (3) months of employment, and a paid time off policy that includes vacation time, personal time, sick time, floating holidays, and eleven (11) company holidays. Additional voluntary benefits include flexible spending and health savings accounts, life and AD&D insurance, short‑ and long‑term disability coverage, legal assistance, and supplemental plans such as pet, critical illness, accident, and hospital indemnity insurance. We also provide voluntary commuter benefits, family planning and care resources, well‑being initiatives, and peer‑to‑peer recognition programs; demonstrating our ongoing commitment to building a culture where our people feel empowered, supported, and inspired to do their best work.

Please note: These benefits are offered exclusively to permanent full‑time employees. Contractors are not eligible for benefits through Legend Biotech.

Pay Range (Base Pay)

$96,267 USD - $126,351 USD

EEO Statement

It is the policy of Legend Biotech to provide equal employment opportunities without regard to actual or perceived race, color, creed, religion, national origin, ancestry, citizenship status, age, sex or gender (including pregnancy, childbirth, related medical conditions and lactation), gender identity or gender expression (including transgender status), sexual orientation, marital status, military service and veteran status, disability, genetic information, or any other protected characteristic under applicable federal, state or local laws or ordinances.

Employment is at‑will and may be terminated at any time with or without cause or notice by the employee or the company.

For information related to our privacy notice, please review: Legend Biotech Privacy Notice.