Sr. Scientist

Legend Biotech; Philadelphia (Philadelphia County); On-site; USD 140,000 - 210,000; Full time

Benefits offered by this job

Full-time position

Legend Biotech benefits

Job summary

Legend Biotech in Philadelphia seeks an initiative-taking and creative scientist to advance next-generation cell therapies within our Philadelphia R&D team. The role focuses on in‑vivo CAR research with emphasis on immunology and oncology, requiring passion and the ability to manage multiple projects.

The ideal candidate will hold a PhD in Immunology or related discipline, with 4+ years in cell and gene therapy, strong flow cytometry and immunoassay experience, and a collaborative, fast-paced

Qualifications

• PhD in Immunology or related discipline.
• At least 4 years in cell and gene therapy; in‑vivo CAR‑T experience preferred.
• Experience with immune cell‑based analytics and assays (multiparameter flow cytometry and cytokine assays).

Responsibilities

• Lead design and optimization of in vivo CAR‑T research.
• Dissect literature to identify novel in vivo cell therapy solutions.
• Isolate immune cells and evaluate CAR-virus in vitro and in vivo.
• Perform solid tumor research using cell biology techniques.
• Generate and manage data with ELN; present results to groups.
• Maintain GLP and EHS compliance.

Skills

Excellent verbal and written comms

Collaborative / cross-functional

Research planning and execution

Independent / proactive

Education

PhD in Immunology or related

Tools

Flow cytometry

ELN

Lentivirus production

Job description

Legend Biotech is a global biotechnology company dedicated to treating, and one day curing, life‑threatening diseases. Headquartered in Somerset, New Jersey, we develop advanced cell therapies across a diverse array of technology platforms, including autologous and allogenic chimeric antigen receptor T‑cell, T‑cell receptor (TCR‑T), and natural killer (NK) cell‑based immunotherapy. From our three R&D sites around the world, we apply these innovative technologies to pursue the discovery of safe, efficacious and cutting‑edge therapeutics for patients worldwide.

Legend Biotech entered into a global collaboration agreement with Janssen, a pharmaceutical company of Johnson & Johnson, to jointly develop and commercialize ciltacabtagene autolecuel (cilta‑cel). Our strategic partnership combines the strengths and expertise of both companies to advance the promise of an immunotherapy in the treatment of multiple myeloma.

Role Overview

We are seeking an initiative‑taking and creative scientist to grow our pipeline efforts. The candidate will be part of Legend Biotech’s Philadelphia R&D team, whose aim is to research, develop and advance next‑generation cell therapies using innovative in‑vivo delivery technologies and create novel CAR therapies to treat a wide range of cancer and autoimmune disease indications. This position focuses on in‑vivo CAR and requires enthusiasm, passion, outstanding skills and a desire to create new medicines for patients. Expertise in immunology and/or oncology is required. The ideal candidate is highly motivated, enjoys a fast‑paced biotech environment, thrives in a collaborative work environment and can advance multiple projects concurrently.

Key Responsibilities

• Lead, design and optimize research with the aim of exploring next‑generation cell therapies using in‑vivo CAR‑T.
• Contribute to project creation and formation through dissection of published literature to find novel solutions to in‑vivo cell therapy problems.
• Isolate immune cells from leukopak or blood of healthy donors or patients and evaluate the in‑vivo CAR virus using a battery of in‑vitro assays and in‑vivo mouse models.
• Perform treatment of solid tumor research requiring cell biology techniques including cell culture, transfection, FACS, and cell‑based functional assays.
• Package and titer engineered viruses to infect immune cells in vitro and in vivo; characterize virus particles with protein and PCR‑based assays; measure transduction rate using flow and VCN analysis.
• Generate, manage, evaluate, and maintain critical data in a highly organized manner, including the use of ELN.
• Deliver results to meet timelines with accountability through presentation to a wide range of audiences at internal group meetings and other forums.
• Maintain compliance with GLP and EHS protocols.

Requirements

• PhD in Immunology or a related discipline.
• At least 4 years of experience in cell and gene therapy; in‑vivo CAR‑T experience preferred.
• Extensive experience in immune cell‑based analytics and assay development, including multi‑parameter flow cytometry and immunogenicity assays such as cytotoxicity assay and cytokine release ELISA/MSD multiplex assays.
• Experience with lentivirus particle characterization and quantification using molecular (VCN) and flow‑based assays.
• Experience with solid tumor models and in‑vivo cell‑specific gene delivery is a plus.
• Track record of productivity demonstrated by publications or patents.
• Ability to work independently to plan and timely execute research projects.
• Deep knowledge of immunology and immunotherapy; a deep understanding of solid tumor models is preferred.
• Proficiency in advanced gene delivery methods using LVV, VLP or LNP technologies.
• Strong experience with lentivirus production, titration and transduction.
• Working knowledge of molecular biology and cellular biology for design and evaluation of modified viral vectors.
• Strong multitasking, problem‑solving and collaborative skills.
• Excellent verbal and written communication skills.

Benefits

These benefits are offered exclusively to permanent full‑time employees. Contractors are not eligible for benefits through Legend Biotech.

EEO Statement

It is the policy of Legend Biotech to provide equal employment opportunities without regard to actual or perceived race, color, creed, religion, national origin, ancestry, citizenship status, age, sex or gender (including pregnancy, childbirth, related medical conditions, and lactation), gender identity or gender expression (including transgender status), sexual orientation, marital status, military service and veteran status, disability, genetic information, or any other protected characteristic under applicable federal, state or local laws or ordinances.

Employment is at-will and may be terminated at any time with or without cause or notice by the employee or the company.

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