Sr. Research Associate Scientist, Benchmarking

Xaira Therapeutics; Seattle (WA); On-site; USD 110,000 - 135,000; Full time

Job summary

An innovative biotechnology company is seeking a dynamic Sr. Research Associate Scientist to advance molecular screening platforms and protein engineering. This role offers the opportunity to drive innovation across multidisciplinary teams, ensuring high throughput in antibody discovery efforts. You will implement cutting-edge screening technologies and collaborate with experts in bioinformatics and protein design. If you're passionate about transforming the drug discovery process and thrive in a collaborative environment, this position is perfect for you, providing a platform for significant contributions to groundbreaking projects.

Benefits

Disability Insurance

Paid Paternity Leave

Paid Maternity Leave

401(k)

Vision Insurance

Medical Insurance

Qualifications

• 3-5 years of industry experience in large molecule hit identification.
• Experience building and screening antibody yeast and phage display libraries.

Responsibilities

• Build and screen HT protein library benchmarking studies for antibody discovery.
• Collaborate closely with Bioanalysts to ensure library quality.

Skills

Molecular Biology

Protein Engineering

High-Throughput Screening

Antibody Discovery

Project Management

Bioinformatics

Education

Ph.D. in Molecular Biology

Ph.D. in Microbiology

Ph.D. in Synthetic Biology

Tools

Yeast Display

Phage Display

Job description

Join to apply for the Sr. Research Associate Scientist, Benchmarking role at Xaira Therapeutics

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Join to apply for the Sr. Research Associate Scientist, Benchmarking role at Xaira Therapeutics

Xaira Therapeutics is an integrated biotechnology company driving advances in artificial intelligence to learn the language of life and transform how we treat disease. The company seeks to rethink the drug discovery and development process from end-to-end by bringing together leading talent across three core areas: machine learning research to better understand biology, expansive data generation to power new models, and robust therapeutic product development to treat disease. Xaira is headquartered in the San Francisco Bay Area, Seattle and London.

Position Overview

You will be responsible for advancing molecular screening platforms, protein engineering, and data-driven discovery methodologies in the context of antibody discovery workflows. You will play a key role in driving innovation across multidisciplinary teams and ensuring high throughput and efficiency in antibody discovery efforts.

Key Responsibilities

• Molecular Engineering: Build and screen HT protein library benchmarking studies for antibody discovery. Evaluate libraries for quality and metrics, then optimize vector designs for library builds and evaluation.
• Method and Library Validation: Evaluate and validate new library designs through routine library benchmarking. Collaborate closely with Bioanalysts to quickly ensure library quality prior to discovery screening.
• Implement Innovative Screening Technologies: Design, qualify, and productionize high-throughput molecular product screening technologies for data generation and hit identification.
• Establish workflows for hit selection, isolation, and purification, reducing turnaround times for lead validation as processes are modified.
• Project management: Coordinate the synthesis, build and validation of design libraries. Ensure screening reagents, controls and assays are qualified and in supply prior to screening. Report on screening initiatives to establish baseline metrics, capturing issues to be addressed quickly.
• Cross-Functional Collaboration: Partner with bioinformatics, bioanalysts, and protein design teams to integrate drug discovery with computational methods. Coordinate with screening teams to gate the delivery of qualified libraries.
• Data Generation and Analysis: Utilize cutting-edge methodologies to generate high-throughput data, enabling the development of protein therapeutics to challenging targets while gaining functional insights into library designs, builds and screening.

Qualifications

• Ph.D. in Molecular Biology, Microbiology, Synthetic Biology or related field
• 3-5 years of industry experience in large molecule hit identification, with a strong focus on high-throughput screening, yeast and phage display, antibody discovery and engineering.
• Experience building and screening antibody yeast and phage display libraries is required.
• Proven track record of scaling systems for enhanced throughput and efficiency
• Strong background in large-scale molecular biology techniques, including phage and yeast display library builds and screening.
• Familiarity with bioinformatics and machine learning for data integration and target discovery.
• Excellent organizational and project management skills.
• Proven ability to collaborate effectively across multidisciplinary teams.
• Experience with managing lab infrastructure from scratch.
• Prior experience in developing workflows for hit validation, isolation, and purification.
• Prior work in metagenomics and protein engineering pipelines.

Compensation

We offer a competitive compensation and benefits package, seeking to provide an open, flexible, and friendly work environment to empower employees and provide them with a platform to develop their long-term careers. A Summary of Benefits is available for all applicants. We offer a competitive package that includes base salary, bonus, and equity. The base pay range for this position is expected to be $110,000-$135,000 annually; however, the base pay offered may vary depending on the market, job-related knowledge, skills and capabilities, and experience.

Xaira Therapeutics an equal-opportunity employer. We believe that our strength is in our differences. Our goal to build a diverse and inclusive team began on day one, and it will never end.

TO ALL RECRUITMENT AGENCIES: Xaira Therapeutics does not accept agency resumes. Please do not forward resumes to our jobs alias or employees. Xaira Therapeutics is not responsible for any fees related to unsolicited resumes.

Seniority level

• Seniority level

  Mid-Senior level

Employment type

• Employment type

  Full-time

Job function

• Job function

  Research and Science

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Inferred from the description for this job

Disability insurance

Paid paternity leave

Paid maternity leave

401(k)

Vision insurance

Medical insurance

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