Sr. Research Associate

VRS Recruitment; Redwood City (CA); On-site; USD 80,000 - 120,000; Full time

Job summary

A leading company in precision oncology seeks a Bioanalytical Scientist responsible for developing LC-MS/MS methods and conducting pharmacokinetic studies. The ideal candidate will possess a strong background in pharmaceutical sciences, with hands-on experience in mass spectrometry and bioanalytical analysis. Join a dynamic team committed to advancing targeted therapies for cancer treatment.

Qualifications

• 5+ years of relevant industry experience or 3+ years of postgraduate working experience.
• Hands-on experience in LC-MS method development and operation.
• Strong communication and organizational skills.

Responsibilities

• Develop and perform LC-MS/MS-based methods for quantification of compounds.
• Conduct in vitro ADME and PK studies.
• Analyze data and prepare experimental reports.

Skills

LC-MS/MS system operation

Bioanalytical analysis

Metabolite identification

Data analysis

Team collaboration

Education

Bachelor/Master’s degree in Pharmaceutical Sciences

Tools

LC-MS/MS

High-Resolution MS

Job description

Revolution Medicines is a clinical-stage precision oncology company focused on developing novel targeted therapies to inhibit frontier targets in RAS-addicted cancers. The company’s R&D pipeline comprises RAS(ON) Inhibitors designed to suppress diverse oncogenic variants of RAS proteins, and RAS Companion Inhibitors for use in combination treatment strategies. As a new member of the Revolution Medicines team, you will join other outstanding scientists in a tireless commitment to patients with cancers harboring mutations in the RAS signaling pathway.

The Opportunity:

Develop LC-MS/MS-based methods for quantification of compounds in various matrices (buffer, blood, plasma, tissue homogenates, etc) to support in vitro ADME, pharmacokinetic, and toxicokinetic studies.
Develop high-resolution mass spectrometry (HRMS) methods for metabolite identification and profiling studies for preclinical and clinical samples.
Perform mechanistic in vitro ADME assays, such as metabolic stability studies in various biological matrices (including hepatocytes, microsomes, blood, plasma, etc.).
Perform data analysis, generate experimental reports, and present the data to teams; Archive raw data and finalized reports to electronic system and electronic notebook.
Assist in the operation, maintenance, and troubleshooting of LC-MS/MS instruments.
Ensure a safe and well-organized DMPK lab environment.

Required Skills, Experience, and Education:

• Bachelor/Master’s degree in Pharmaceutical Sciences or a related scientific discipline, with 5+ of relevant industry experience or 3+ years of postgraduate working experience.
• Hands-on experience in operating and maintaining an LC-MS/MS system and/or a High-Resolution MS system.
• Hands-on experience in LC-MS method development for bioanalytical analysis and/or metabolite identification studies.
• Knowledge of biological sample preparation and extraction techniques for downstream LC-MS/MS and/or HRMS analysis.
• Ability to conduct multiple laboratory and project tasks efficiently.
• Ability to work in a team-oriented environment with flexibility.
• Highly organized, detail-oriented, excellent record-keeping skills, and being able to adapt to a dynamic and fast-paced environment.
• Strong written and verbal communication skills, with a demonstrated ability to collaborate effectively in a team environment.

Preferred Skills:

• Hands-on experience in SCIEX QTRAP and/or Thermo Scientific Q Exactive mass spectrometers.
• Hands-on experience in HPLC/UPLC method development and/or bioanalytical method development in compliance with regulatory requirements.
• Working experience in DMPK lab.