Sr Principal Scientist - Imaging

Regeneron Pharmaceuticals; United States; Remote; USD 148,000 - 242,000; Full time

Job summary

An established industry player is seeking a Senior Principal Scientist to lead imaging biomarker strategies in clinical trials. This role offers the chance to collaborate with cross-functional teams, guiding the design of innovative imaging approaches to evaluate the efficacy and safety of groundbreaking therapies. You will play a key role in developing and validating novel imaging-based biomarkers while ensuring high-quality imaging data delivery. If you are passionate about advancing clinical imaging in a fast-paced environment and possess a strong analytical mindset, this opportunity could be your next career milestone.

Qualifications

• PhD or MD/PhD with 6+ years in clinical imaging, especially in cardiovascular/metabolic areas.
• Expertise in various imaging modalities and clinical trial experience preferred.

Responsibilities

• Lead imaging biomarker strategy and implementation in clinical trials.
• Collaborate with teams to develop and validate novel imaging biomarkers.

Skills

Analytical Skills

Problem-Solving Skills

Communication Skills

Imaging Modalities Knowledge

Education

PhD or MD/PhD

Tools

MRI

CT

Ultrasound

Echocardiography

Job description

The Senior Principal Scientist is responsible for spearheading the imaging biomarker strategy and implementation across cardiovascular and metabolic indications in early- and late-phase clinical trials. This role involves collaboration with cross-functional study teams where you will lead the design of complex imaging approaches to test the efficacy and safety of Regeneron products. In this role, you will be responsible for developing and validating novel imaging-based biomarkers to address the needs of the Regeneron experimental therapies.

As a Senior Principal Scientist in Clinical Imaging you will:

• Collaborate closely with Research and Global Development colleagues to formulate appropriate imaging biomarker strategies to inform and advance the Regeneron clinical pipeline.
• Provide leadership during the strategy phase of study design, guiding the team on all imaging aspects of the study, presenting the imaging components of the integrated biomarker strategy to senior management for endorsement, and authoring of key study documents.
• Work closely with Clinical Imaging Operations and Clinical Trial Management to ensure the delivery of high-quality imaging data in clinical studies. This includes drafting imaging manuals and other documents for the trial, supporting the clinical team during the study start-up phase, and monitoring data integrity throughout the trial.
• Supervise imaging Clinical Research Organizations (CROs) to ensure execution of imaging components in the trial, timely address any image quality issues, and ensure flawless delivery of key study imaging data and achievements.
• Identify gaps in imaging assessments for particular indications and propose novel biomarkers, and spearhead validation through collaboration with other functions within Regeneron or external institutions.
• Support regulatory submission packages as the imaging subject matter expert.

This role requires that you:

• Work efficiently in a fast-paced, collaborative environment.
• Communicate extremely effectively across clinical teams and functions, and with senior management.
• Possess a broad knowledge of imaging and understand the challenges of image standardization across sites and countries.
• Have strong analytical and problem-solving skills.
• Thrive in addressing complex problems with innovative methods.

To be considered for this position, we expect you to have completed a PhD or MD/PhD program, with a minimum of 6 years of experience in clinical imaging, specifically within cardiovascular and/or metabolic domains. We believe you should have extensive expertise in the acquisition and analysis of various imaging modalities, including MRI, CT, ultrasound, and echocardiography. While experience in industry-sponsored clinical trials is preferred, it is not mandatory.

Salary Range (annually)

$148,300.00 - $241,900.00