Sr. Manager, Enterprise Cyber Defense

Ladders; United States; Remote; USD 181,000 - 302,000; Full time

Benefits offered by this job

Medical, dental, vision coverage

Wellness programs

Flexible work arrangements

Unlimited PTO

Training & mentorship

Job summary

Ladders is seeking a Sr. Manager, Enterprise Cyber Defense to shape a global cyber defense function for a healthcare-focused leader. This remote role is US-based with no visa sponsorship. You will define strategy, build scalable capabilities, and align detection, response, and readiness with business risk.

Lead cross-functional incident response, threat hunting, and readiness exercises, driving measurable coverage in a highly regulated environment.

Qualifications

• BS/MS in CS/Cybersecurity, IT, or Engineering, or equivalent experience.

Responsibilities

• Define and execute an enterprise cyber defense strategy aligned with business risks.

Skills

Cybersecurity leadership

Threat hunting

Incident response

Security operations

Automation/AI in security

MITRE ATT&CK

Global team leadership

Education

BS/MS in CS/Cybersecurity/IT/Engineering

Tools

SIEM

SOAR

Cloud security tools

Job description

For our client, we are seeking a Sr. Manager, Enterprise Cyber Defense to join the team of a leader in the Healthcare space. This leader will shape a global cyber defense function that protects the enterprise against evolving threats while strengthening detection, response, and readiness. The role partners closely with security, technology, and business stakeholders to reduce risk and improve resilience across the organization. It is well suited for a cybersecurity leader who can build scalable capabilities, guide cross-functional incident response, and drive measurable coverage in a highly regulated healthcare environment. Location: Remote - US based candidates only, no visa sponsorship available. Compensation: $181,000 - $301,600 annually.

Responsibilities

• Define and execute an enterprise cyber defense strategy aligned with business risks
• Build and lead a high-performing global cyber defense organization
• Mature a threat-informed detection engineering lifecycle to improve measurable coverage
• Lead cyber response to emerging threats requiring cross-functional investigation
• Establish proactive threat hunting and adversary-validation capabilities
• Own the cyber readiness program, including exercises and assessments
• Provide oversight for high-severity cyber incidents and ensure lessons learned are applied

Qualifications

• BS/MS in Computer Science, Cybersecurity, Information Technology, Engineering, or a related field, or equivalent experience
• 10+ years in cybersecurity, IT, or engineering, including 5+ years in cyber defense, detection, and response
• Proven success in building and scaling enterprise cyber defense capabilities
• Strong understanding of detection and response technologies such as SIEM, SOAR, and cloud security
• Deep knowledge of adversary behaviors and threat hunting methodologies, preferably with MITRE ATT&CK experience
• Experience with automation and AI in security operations, including oversight of automated outputs
• Ability to lead globally distributed teams and communicate technical risks effectively

Benefits

• Comprehensive medical, dental, and vision coverage, plus wellness programs
• Flexible work arrangements and unlimited paid time off for work-life balance
• Access to in-house training, development programs, and career mentorship
• Opportunities to attend security conferences for professional growth
• Inclusive and diverse work environment that values teamwork and collaboration
• Engagement with a purpose-driven employee community

Our client is an equal opportunity employer. We encourage you to apply even if you don't meet every qualification- your background could be exactly what this team needs.