Spatial Sequencing Specialist

Singular Genomics Systems, Inc.; San Diego (CA); On-site; USD 75,000 - 88,000; Full time

Benefits offered by this job

Equity compensation

Job summary

Singular Genomics is seeking a Spatial Sequencing Associate 2 to support engineers and scientists in running customer tissue samples on the G4X Spatial Sequencer. The ideal candidate has hands-on molecular biology skills and experience with DNA/RNA purification, PCR, and NGS workflows.

You will help optimize workflows, provide guidance on controls, and maintain the instrument with daily runs and data analysis; familiarity with fluorescence imaging and immunoassays is a plus.

Qualifications

• BS in a Science or Engineering field or 5 years of working experience in equivalent field.
• Strong molecular biology laboratory skills, demonstrated by work experience.
• Hands-on experience with multiplexed and immunoassay workflows (required).
• Strong analytical and documentation skills; experience maintaining accurate, detailed records.
• Experience with running, maintaining, and troubleshooting lab equipment.
• Working knowledge of fluorescence microscopy and imaging-based readouts is a strong plus.
• Familiarity with spatial biology platforms and workflows is a strong plus.
• Experience interpreting NGS-based transcriptomic and proteomic data is a strong asset.
• Desire and ability to work in a small interdisciplinary team to develop new technologies at a rapid pace.

Responsibilities

• Execute experiments to characterize antibody activity using immunofluorescence or IHC across diverse tissue types and conditions.
• Support antibody validation efforts using molecular biology techniques (e.g. SDS-PAGE), immunoassays, and/or G4X spatial biology assay across various tissue types.
• Day-to-day operation of the G4X sequencer.
• Manually prepare customer samples provided for spatial sequencing.
• Load consumables and program sequencing runs.
• Perform primary analysis of run data.
• Perform regular instrument maintenance.
• Daily run metrics and quality of sequencing performance review.
• Complete documentation to support data capture, forms, logbooks, and inventory batch records.
• Contribute to late-stage optimization of spatial biology workflows, ensuring readiness for product launch.
• Scheduling, usage forecasting and inventory management of consumables.

Skills

Molecular biology

Immunoassays

Fluorescence microscopy

NGS data analysis

Documentation

Lab equipment troubleshooting

Education

BS in Science or Engineering

Job description

Singular Genomics is seeking a Spatial Sequencing Associate 2 to support engineers and scientists in running customer tissue samples on the G4X Spatial Sequencer. The ideal candidate has hands-on molecular biology skills and experience with DNA/RNA purification, PCR, and NGS workflows.

You will help optimize workflows, provide guidance on controls, and maintain the instrument with daily runs and data analysis; familiarity with fluorescence imaging and immunoassays is a plus.