SiRNA Chemistry Advisor (Part-Time)

OS Therapeutics; United States; Presencial; USD 83.000 - 138.000; A tiempo parcial

Descripción de la vacante

OS Therapeutics is seeking a part-time Chemistry Consultant with industry experience in siRNA therapeutics to support discovery and preclinical development, working closely with the leadership team. This is a lean, fast-paced advisory role in a startup environment.

The consultant will provide expert guidance on oligonucleotide design and optimization, review chemistry data, and advise on candidate development, including external partner coordination for early CMC activities.

Formación

• PhD in Chemistry (organic, medicinal, or nucleic acid chemistry preferred).
• Demonstrated industry track record in oligonucleotide therapeutics, including advancing programs to candidate nomination or IND.
• Deep expertise in oligonucleotide chemistry, including chemical modifications, conjugation, and delivery.
• Familiarity with oligonucleotide CMC, analytical characterization, and regulatory considerations.

Responsabilidades

• Advise on siRNA design and optimization, including sequence selection, chemical modifications, and conjugation strategies.
• Review and interpret chemistry and analytical data and provide recommendations to the program and leadership teams.
• Advise on candidate selection and development, including developability and readiness for preclinical studies.
• Guide work with external partners (CROs/CDMOs) on oligonucleotide synthesis, scale-up, and early CMC as needed.

Conocimientos

Oligonucleotide design

Data interpretation

Collaborative skills

Project management

Educación

PhD in Chemistry (organic, medicinal, or nucleic acid chemistry preferred)

Descripción del empleo

OS Therapeutics is seeking a part-time Chemistry Consultant with industry experience in siRNA therapeutics to support discovery and preclinical development, working closely with the leadership team. This is a lean, fast-paced advisory role in a startup environment.

The consultant will provide expert guidance on oligonucleotide design and optimization, review chemistry data, and advise on candidate development, including external partner coordination for early CMC activities.