Consultant, Chemistry

OS Therapeutics; United States; On-site; USD 83,000 - 138,000; Part time

Job summary

OS Therapeutics is seeking a part-time Chemistry Consultant with industry experience in siRNA therapeutics to support discovery and preclinical development, working closely with the leadership team. This is a lean, fast-paced advisory role in a startup environment.

The consultant will provide expert guidance on oligonucleotide design and optimization, review chemistry data, and advise on candidate development, including external partner coordination for early CMC activities.

Qualifications

• PhD in Chemistry (organic, medicinal, or nucleic acid chemistry preferred).
• Demonstrated industry track record in oligonucleotide therapeutics, including advancing programs to candidate nomination or IND.
• Deep expertise in oligonucleotide chemistry, including chemical modifications, conjugation, and delivery.
• Familiarity with oligonucleotide CMC, analytical characterization, and regulatory considerations.

Responsibilities

• Advise on siRNA design and optimization, including sequence selection, chemical modifications, and conjugation strategies.
• Review and interpret chemistry and analytical data and provide recommendations to the program and leadership teams.
• Advise on candidate selection and development, including developability and readiness for preclinical studies.
• Guide work with external partners (CROs/CDMOs) on oligonucleotide synthesis, scale-up, and early CMC as needed.

Skills

Oligonucleotide design

Data interpretation

Collaborative skills

Project management

Education

PhD in Chemistry (organic, medicinal, or nucleic acid chemistry preferred)

Job description

Company: OS Therapeutics Inc., a Delaware corporation (“OS Tx”)

About OS Tx

OS Therapeutics is a fast-growing US biotech company build around a mission to make the impossible possible for patients facing difficult-to-treat diseases. We are pioneering next-generation therapeutics that turn breakthrough science into life-changing therapies. That vision is built on a validated scientific platform, a focused strategy with a clear development roadmap, and a team with a track record of disciplined execution. Together, they position us toward a bold ambition: bringing transformative medicines to the patients and improving lives with speed and scientific discipline.

Position Overview

OS Therapeutics is seeking a Chemistry Consultant (part-time) with industry experience in siRNA therapeutics to support our discovery and preclinical development efforts, working closely with the leadership team. Operating in a lean, fast-paced startup environment, the consultant will provide expert guidance on oligonucleotide design and optimization, review chemistry data, and advise on candidate development. This is a high-impact advisory engagement for an experienced oligonucleotide chemist who enjoys translating chemistry insights into differentiated drug candidates.

Key Responsibilities

• Advise on siRNA design and optimization, including sequence selection, chemical modifications, and conjugation strategies.
• Review and interpret chemistry and analytical data and provide recommendations to the program and leadership teams.
• Advise on candidate selection and development, including developability and readiness for preclinical studies.
• Guide work with external partners (CROs/CDMOs) on oligonucleotide synthesis, scale-up, and early CMC as needed.

Qualifications

• PhD in Chemistry (organic, medicinal, or nucleic acid chemistry preferred)
• Demonstrated industry track record in oligonucleotide therapeutics, including advancing programs to candidate nomination or IND.
• Deep expertise in oligonucleotide chemistry, including chemical modifications, conjugation, and delivery.
• Familiarity with oligonucleotide CMC, analytical characterization, and regulatory considerations.

Desired Attributes

• Hands-on, pragmatic, and resourceful—comfortable rolling up sleeves and executing.
• Strong interpersonal skills and the ability to build trust across scientific, operational, and partner ecosystems.
• High personal integrity and ability to handle confidential information with discretion.

Why Join OS Tx?

• Opportunity to shape and build a pioneering biotech company at a formative stage.
• Collaborative and innovative culture with direct exposure to scientific and corporate decision-making.
• Meaningful career growth opportunities as the company scales toward clinical development.
• Competitive compensation and benefits package (details below).

OS Tx is an equal opportunity employer. We celebrate diversity and are committed to creating an inclusive environment for all employees.