Senior Vector Development Scientist: Gene Delivery Innovator

Weill Cornell Medicine; New York (NY); On-site; USD 101,000 - 126,000; Full time

Job summary

Weill Cornell Medicine's MCC Laboratories in New York invites applications for a Senior Principal Scientist – Vector Development. The role leads design of lentiviral vectors, transposon-based architectures, and mRNA delivery systems for functional genomics and therapeutic development, in a fast-paced translational research setting.

The successful candidate has a PhD with 10+ years in gene delivery or molecular cloning, and can mentor teams while driving cross-disciplinary collaboration across

Qualifications

• PhD in Molecular Biology, Virology, Genetic Engineering, Synthetic Biology, or related field.
• 10+ years of postdoctoral and/or industry experience in gene delivery or molecular cloning.
• Proven track record designing and implementing complex genetic constructs.

Responsibilities

• Lead design, construction, and optimization of complex plasmid systems for lentiviral vectors with multi-gene cargos.
• Lead engineering of self-inactivating lentiviral backbones and optimize element interactions.
• Develop transposon-based systems with donor vector architecture and transposase strategies.
• Design site-specific CRISPR/transposon integration approaches.
• Engineer expression systems for constitutive/inducible/multiplexed gene expression in ex vivo/in vivo T cell engineering.
• Define platform constraints and recommend delivery approaches.
• Lead development of innovative mRNA delivery constructs to maximize stability and translation.
• Provide cross-functional technical leadership across vector production, cell engineering, and validation.
• Mentor scientists and researchers and drive data-driven decisions.

Skills

Lentiviral design

Transposon systems

mRNA delivery systems

CRISPR integration

Gene expression tuning

DNA sequence analysis

Education

PhD in Molecular Biology or related field

Tools

SnapGene

Benchling

Geneious

Job description

Weill Cornell Medicine's MCC Laboratories in New York invites applications for a Senior Principal Scientist – Vector Development. The role leads design of lentiviral vectors, transposon-based architectures, and mRNA delivery systems for functional genomics and therapeutic development, in a fast-paced translational research setting.

The successful candidate has a PhD with 10+ years in gene delivery or molecular cloning, and can mentor teams while driving cross-disciplinary collaboration across