Senior Translational Scientist - IBD Biomarkers & Omics

Genentech; San Francisco (CA); On-site; USD 100,000 - 186,000; Full time

Benefits offered by this job

Discretionary bonus

Job summary

Genentech's Translational Medicine OMNI department seeks a Scientist 3 to advance our IBD biomarker discovery program using human biospecimens and high-dimensional omics. The role blends wet-lab work with data science to identify targets and biomarkers that inform clinical development.

You will design experiments, develop organoid and co-culture models, and apply scRNA-seq/CITE-seq analyses to drive translational insights in a collaborative, fast-paced environment.

Qualifications

• PhD with post-doctoral experience in Immunology, Cell/Molecular Biology, Mucosal Biology, Biochemistry, or related life sciences.
• Minimum of 3 years hands-on experience in immunology or mucosal biology, ideally focused on IBD.
• Technical expertise in benchtop techniques (flow cytometry, multiplex immunoassays, ELISA, RT-qPCR, histology) and single-cell workflows (scRNA-seq, CITE-seq).
• Analytical proficiency in coding with R or Python for omics data analysis.
• Independent design and troubleshooting of complex scientific studies while managing multiple priorities.

Responsibilities

• Design and perform experimental studies using patient-derived human biospecimens (intestinal tissue biopsies, blood, stool) to unravel disease mechanisms in IBD.
• Establish and execute complex human-relevant model systems (including intestinal organoids, primary immune cell co-cultures, and air-liquid interface systems) to investigate pathway biology and therapeutic mechanisms of action.
• Develop, qualify, and execute custom assays (e.g., multiplex immunoassays, ELISA, flow cytometry, histology) to generate pharmacodynamic and disease-relevant readouts.
• Analyze and integrate high-dimensional datasets (scRNA-seq, CITE-seq, spatial transcriptomics, proteomics) using R or Python to discover biomarkers and support patient stratification.
• Support clinical biomarker research strategies by translating laboratory findings into actionable insights for cross-functional clinical development programs.
• Evaluate and implement emerging technologies and experimental platforms to continually advance translational research capabilities in IBD.
• Collaborate closely with cross-functional partners across Research, Bioanalytical Sciences, Biostatistics, Computational Sciences, and Clinical Development to present findings and drive project goals.

Skills

Flow cytometry

Multiplex immunoassays

ELISA

RT-qPCR

Histology

scRNA-seq

CITE-seq

Python

R

Independent research

Education

PhD

Post-doctoral experience

Tools

R

Python

Organoids

Job description

Genentech's Translational Medicine OMNI department seeks a Scientist 3 to advance our IBD biomarker discovery program using human biospecimens and high-dimensional omics. The role blends wet-lab work with data science to identify targets and biomarkers that inform clinical development.

You will design experiments, develop organoid and co-culture models, and apply scRNA-seq/CITE-seq analyses to drive translational insights in a collaborative, fast-paced environment.