Senior T Cell Immunologist & IND Strategy Lead

NIF; Boston (MA); Presencial; USD 140.000 - 220.000; Jornada completa

Ventajas ofrecidas por este puesto de trabajo

Impactful Mission

Collaborative Culture

High Growth

Comprehensive Benefits

Descripción de la vacante

Basecamp Research is seeking a highly capable Senior T Cell Immunologist to lead the biology behind our in vivo cell therapy programs in oncology and autoimmunity from primary human cell assays through IND-enabling studies. You will own the immunology strategy, design studies, and perform a substantial portion of the work while mentoring a small team in Boston.

Collaborating with gene editing, protein engineering, and AI teams, you will characterize novel editing enzymes in primary human T cells

Formación

• PhD in immunology, molecular biology, bioengineering, or related life sciences with substantial industry cell/gene therapy experience.
• Deep hands-on expertise in primary human T cell biology: isolation, activation, expansion, transfection and transduction, and functional characterization.
• Experience with gene editing in primary immune cells (nucleases, base/prime editors, transposons, recombinases/integrases, or equivalent).
• Expertise in multiparameter flow cytometry using antibody panels and fluorescent reporters, including panel design and analysis.
• Fluency with ddPCR, qPCR, NGS library preparation and QC, and interpretation of on/off-target analytics.
• Experience designing and overseeing in vivo mouse studies, including CRO management.
• Excellent communication skills with internal and external stakeholders.

Responsabilidades

• Own T cell immunology strategy across our oncology and autoimmunity programs and turn program goals into a concrete assay and study plans.
• Lead translation into in vivo models: mouse studies (humanized, syngeneic, and relevant disease models) and NHP studies for PK/PD, biodistribution, persistence, and immunogenicity, in partnership with CROs.
• Drive the pharmacology and safety components of IND-enabling work: GLP and non-GLP toxicology study design and CRO oversight, biodistribution and insertional mutagenesis assessment, and authorship of pharmacology and toxicology sections of regulatory filings.
• Represent our data in pre-IND and agency interactions, partner meetings, and internal governance.
• Design, run, and interpret in vitro potency and specificity assays in primary human T cells and cell lines: activation, proliferation, antigen-specific cytotoxicity and co-culture killing, repeat stimulation and exhaustion, cytokine release, and phenotyping by multiparameter and spectral flow cytometry.
• Mentor scientists and grow the team as the programs scale.

Conocimientos

T cell biology

Gene editing in immune cells

Multiparameter flow cytometry

ddPCR/qPCR/NGS

In vivo mouse studies

Communication

Educación

PhD in immunology or related field

MSc with hands-on experience

Descripción del empleo

Basecamp Research is seeking a highly capable Senior T Cell Immunologist to lead the biology behind our in vivo cell therapy programs in oncology and autoimmunity from primary human cell assays through IND-enabling studies. You will own the immunology strategy, design studies, and perform a substantial portion of the work while mentoring a small team in Boston.

Collaborating with gene editing, protein engineering, and AI teams, you will characterize novel editing enzymes in primary human T cells