Cell Therapy Research Scientist / Senior Research Scientist

Kelly; Frederick (MD); Vor Ort; USD 120.000 - 170.000; Vollzeit

Zusammenfassung

Kelly in Frederick, MD seeks a Cell Therapy Research Scientist / Senior Research Scientist to join a Discovery team developing next‑generation cell‑based therapies for autoimmune diseases. The role centers on hands‑on preclinical work evaluating ex vivo and in vivo candidates.

You will design and perform in vitro and in vivo studies, conduct aseptic culture, flow cytometry, ELISA and IVIS imaging, and contribute to mRNA therapeutics and LNP formulation efforts, collaborating with

Qualifikationen

• Master’s degree or higher in biology, chemistry, biochemistry, cell biology, molecular biology, or related field.
• At least 3 years of hands-on industry or academic research experience in preclinical cell therapy workflows.
• Proficiency with aseptic cell culture, primary cell isolation, flow cytometry, ELISA.
• Experience establishing and executing in vivo models and animal handling.
• Strong experimental design, data analysis, documentation, and problem-solving skills.
• Highly organized with attention to detail and ability to manage multiple experiments.

Aufgaben

• Design, execute, and analyze preclinical in vitro and in vivo studies.
• Perform hands‑on lab work including aseptic cell culture, primary cell isolation, flow cytometry, and ELISA.
• Establish and monitor in vivo models, including animal handling and IVIS imaging.
• Support development, characterization, and optimization of mRNA therapeutics and cell therapy candidates.
• Perform and/or support LNP formulation, characterization, QC, and preclinical evaluation.
• Perform and/or support mRNA IVT, QC, application, and optimization.
• Communicate results to support research program decisions and maintain records.

Kenntnisse

Aseptic cell culture

Primary cell isolation

Flow cytometry

In vivo models

ELISA

IVIS imaging

Experimental design

Data analysis

Ausbildung

Master’s degree or higher in Biology/related field

Tools

LNP formulation

mRNA IVT

QC

Jobbeschreibung

Cell Therapy Research Scientist / Senior Research Scientist

Location: Frederick, MD

Schedule: Full-Time | Monday-Friday | First Shift

Work Arrangement: Onsite

Position Overview

We are seeking a highly motivated Cell Therapy Research Scientist / Senior Research Scientist to join an innovative and collaborative Discovery team focused on developing next-generation cell-based therapies for autoimmune diseases.

This position will play an important role in the preclinical evaluation and development of novel ex vivo and in vivo cell therapy candidates, with a strong emphasis on hands-on laboratory research. The successful candidate will design and execute in vitro and in vivo studies, analyze experimental data, and contribute to the advancement of promising therapeutic programs.

The level of the position -Research Scientist or Senior Research Scientist- will be determined based on the candidate’s experience, technical expertise, and qualifications.

Key Responsibilities

• Design, execute, and analyze preclinical in vitro and in vivo studies supporting cell therapy and related therapeutic programs.
• Perform hands‑on laboratory work including aseptic cell culture, primary cell isolation, flow cytometry, and plate‑based assays such as ELISA.
• Establish, conduct, and monitor in vivo models, including animal handling and IVIS imaging.
• Support the development, characterization, and optimization of mRNA‑based therapeutics and cell therapy candidates.
• Perform and/or support LNP formulation, characterization, quality control, and preclinical evaluation.
• Perform and/or support mRNA in vitro transcription (IVT), QC, application, and optimization.
• Analyze, interpret, and communicate experimental results to support research program decisions.
• Maintain accurate, complete, and timely experimental records and documentation.
• Collaborate closely with cross‑functional Discovery team members and external partners.
• Provide occasional oversight of formulation and related activities at local CRO facilities.
• Contribute to laboratory operations and other research activities as assigned.

Required Qualifications

• Master’s degree or higher in Biology, Chemistry, Biochemistry, Cell Biology, Molecular Biology, or a related scientific discipline.
• At least 3 years of hands‑on industry or academic research experience with preclinical cell therapy workflows.
• Demonstrated proficiency with:
• Aseptic cell culture
• Primary cell isolation and handling
• Flow cytometry
• Luminometric and colorimetric plate‑based assays, including ELISA
• Establishment and execution of in vivo models
• Animal handling
• IVIS imaging
• Strong experimental design, data analysis, documentation, and problem‑solving skills.
• Highly organized with exceptional attention to detail and the ability to manage multiple experiments and priorities.
• Ability to work effectively both independently and collaboratively in a fast‑paced research environment.

Preferred Qualifications

• Experience with LNP formulation, characterization, QC, and preclinical studies.
• Experience with mRNA IVT, QC, application, and optimization.
• Expertise in the development and characterization of mRNA therapeutics.
• Knowledge or experience with chimeric antigen receptor (CAR), T‑cell engager (TCE), or related cell therapy platforms.
• Experience working with external CROs or other research partners.
• Experience in therapeutic development for autoimmune or immune‑mediated diseases.