Senior Spatial Biologist, 12-Month Contract

UNAVAILABLE; Seattle (WA); Hybrid; USD 135,000 - 141,000; Full time

Job summary

Bruker Spatial Biology is seeking a Senior Scientist for a 12-month fixed-term contract in Seattle to lead end-to-end spatial biology workflows from FFPE processing to data delivery. The role requires hands-on wet-lab execution, strong troubleshooting, and collaboration with R&D, product development, and external partners.

The ideal candidate has a PhD with 3+ years in spatial biology, proficiency in FFPE, in situ hybridization, IHC/IF, and fluorescence imaging, and the ability to work on-site

Qualifications

• Ph.D. in bioengineering, biomedical engineering, biophysics, chemical biology, cancer biology, or a related discipline with 3+ years’ post-graduate experience.
• Hands-on experience with spatial biology platforms (e.g. CosMx or comparable) – direct wet-bench operation, not analysis-only experience.
• Strong background in FFPE tissue processing, in situ hybridization, and immunohistochemistry/immunofluorescence.
• Experience with fluorescence microscopy and multi-cycle/multiplexed imaging workflows.
• Ability to independently execute, troubleshoot, and QC complex assays against a delivery timeline.

Responsibilities

• Execute spatial multi-omic assays on FFPE tissue specimens per established SOPs, adapting protocols as needed.
• Own end-to-end sample processing: tissue QC/triage, sectioning coordination, staining, probe hybridization, and instrument run setup.
• Perform single-cell spatial data generation and quality control across imaging cycles, flagging and troubleshooting issues in real time.
• Curate, QC, and package datasets for delivery to customers and internal stakeholders on agreed timelines.
• Maintain detailed records: run logs, QC reports, protocol deviations, troubleshooting documentation.
• Communicate progress, data quality issues, and results clearly to the project lead and cross-functional team.
• Collaborate with bioinformatics/data science partners to ensure data formats and metadata meet downstream analysis requirements.
• Maintain and handle biological specimens (BSL-2 tissues) in compliance with biosafety requirements.

Skills

Spatial biology

FFPE tissue processing

In situ hybridization

IHC/IF

Fluorescence microscopy

Troubleshooting assays

Communication skills

Education

Ph.D. in bioengineering/biophysics/related

Tools

CosMx platform

Job description

Bruker Spatial Biology is seeking a Senior Scientist for a 12-month fixed-term contract in Seattle to lead end-to-end spatial biology workflows from FFPE processing to data delivery. The role requires hands-on wet-lab execution, strong troubleshooting, and collaboration with R&D, product development, and external partners.

The ideal candidate has a PhD with 3+ years in spatial biology, proficiency in FFPE, in situ hybridization, IHC/IF, and fluorescence imaging, and the ability to work on-site