Senior Scientist

University of Virginia; Charlottesville (VA); On-site; USD 110,000 - 150,000; Full time

Job summary

University of Virginia's W.M. Keck Biomedical Mass Spectrometry Lab seeks a Senior Scientist to advance proteomics and metabolomics using state‑of‑the‑art instruments to support basic science, the Cancer Center, and clinical projects.

You will prep samples, operate and maintain Orbitrap ID‑X, Vanquish Neo, and Orbitrap Astral systems, and analyze data with Proteome Discoverer and Scaffold. The ideal candidate has a PhD in mass spectrometry or related field, 5+ years MS experience, strong

Qualifications

• Doctoral degree in Mass Spectrometry or closely related field.
• 5+ years of direct experience in mass spectrometry; 10+ years in proteomics/metabolomics.
• Experience with qualitative and quantitative proteomics and metabolomics, LC-MS workflows.
• Experience managing multiple projects across laboratories; strong publication record.
• Demonstrated scientific productivity with excellent written and oral communication.

Responsibilities

• Support the director through sample preparation and operation/maintenance of advanced mass spectrometers (Orbitrap ID-X, Vanquish Neo, Orbitrap Astral).
• Data analysis using Proteome Discoverer, Scaffold, and related software.
• Contribute to development of new technologies in proteomics and metabolomics; support translational research within UVA.
• Collaborate across disciplines and engage investigators in project design and execution.

Skills

Mass spectrometry

Proteomics

Metabolomics

Data analysis

Communication

Project management

Team collaboration

Education

PhD in Mass Spectrometry or related field

Tools

Proteome Discoverer

Scaffold

MS Dial

MetaboAnalyst

Orbitrap Fusion

Orbitrap Astral

Orbitrap ID-X

Job description

The W.M. Keck Biomedical Mass Spectrometry Lab – a part of the Biomolecular Analysis Facility Core at the University of Virginia – seeks a Senior Scientist to expand our work in the areas of proteomics and metabolomics using state‑of‑the‑art instruments to support research within the institution in areas such as basic science research, the Cancer Center, and clinical projects. This position requires expertise and hands‑on experience in biomedical science. The candidate should have documented expertise in mass spectrometry and chromatography as well as protein and small molecule chemistry. You will support the director through sample preparation, operation/maintenance of advanced mass spectrometers (Orbitrap ID‑X – Vanquish Neo and Orbitrap Astral Zoom – Evosep Enzo), and data analysis using advanced software packages (Proteome Discoverer, Compound Discoverer, Scaffold, etc). This work will advance institutional goals in proteomic and metabolomic profiling and translational research.

The ideal candidate will have a proven record of excellent communication and team support. You should be highly motivated and able to work independently when designing and executing experiments. The customer support of researchers within the institution is a high priority. Projects will include use of existing techniques to answer current biological challenges and the development of new technologies in proteomics and metabolomics.

Qualifications

• Doctoral degree, preferably a Ph.D. in Mass Spectrometry or a closely related field.
• Prior experience in qualitative and quantitative proteomics and metabolomics technology and nano‑liquid chromatography and mass spectrometry (LC‑MS; on Orbitrap Fusion, Orbitrap Astral, and/or Orbitrap ID‑X).
• Familiarity with the entire metabolomics and/or proteomics pipeline (including sample preparation, LC and MS operation, and data analysis) and ability to conduct independent projects.
• Experience managing multiple projects across multiple laboratories.
• Demonstrated scientific productivity with excellent written and oral communication skills.
• Attention to detail, ability to learn new technologies, flexibility, and time management.
• 5+ years of direct experience in mass spectrometry or a closely related field and 10+ years in proteomics or metabolomics.
• Collaboration across multiple disciplines and ability to engage investigators in project design, execution, and data analysis.
• Experience in publication and grant writing.Experience with Proteome/Compound Discoverer, Scaffold, MS Dial, MetaboAnalyst, etc.
• Advanced knowledge of Thermo mass spectrometers – operation and maintenance.

Physical Demands

This is primarily a sedentary job involving extensive use of desktop computers. The position occasionally requires traveling some distance to attend meetings.

Salary will be commensurate with education and experience. This is an exempt‑level, benefited position.

Initial appointments and reappointments may be made in increments of one to three years, contingent upon satisfactory performance and the availability of funding.

This position is based in Charlottesville, VA, and must be performed fully on‑site.

Background Checks

Background checks and pre‑employment health screenings will be conducted on all new hires prior to employment.

Equal Opportunity Statement: The University of Virginia is an equal opportunity employer. All interested persons are encouraged to apply, including veterans and individuals with disabilities. Learn more about UVA’s commitment to non‑discrimination and equal opportunity employment.