Senior Scientist

The Rector & Visitors of the University of Virginia; Charlottesville (VA); On-site; USD 110,000 - 140,000; Full time

Job summary

The W.M. Keck Biomedical Mass Spectrometry Lab at the University of Virginia seeks a Senior Scientist to expand proteomics and metabolomics work using state‑of‑the‑art instruments in support of basic science, Cancer Center and clinical projects.

You will lead sample preparation, operate and maintain Orbitrap Fusion, Orbitrap Astral, and Orbitrap ID‑X instruments, and analyze data with Proteome Discoverer, Scaffold and related software, contributing to translational research goals across the

Qualifications

• Doctoral degree in Mass Spectrometry or closely related field.
• Qualitative and quantitative proteomics and metabolomics experience.
• Familiar with LC-MS workflows and Orbitrap instruments.
• Ability to manage multiple projects across laboratories.
• Strong communication and publication record.

Responsibilities

• Prepare samples and operate/maintain advanced mass spectrometers.
• Data analysis using Proteome Discoverer, Compound Discoverer, Scaffold, etc.
• Support director and collaborate across laboratories for translational research.
• Develop and implement new proteomics/metabolomics technologies.

Skills

Mass spectrometry

Proteomics

Metabolomics

LC‑MS

Data analysis

Team collaboration

Education

PhD in Mass Spectrometry

Tools

Proteome Discoverer

Compound Discoverer

Scaffold

MS-Dial

MetaboAnalyst

Orbitrap Fusion

Orbitrap Astral

Job description

The W.M. Keck Biomedical Mass Spectrometry Lab - a part of the Biomolecular Analysis Facility Core at the University of Virginia - seeks a Senior Scientist to expand our work in the areas of proteomics and metabolomics using state-of-the-art instruments to support research within the institution in areas such as basic science research, the Cancer Center, and clinical projects. This position requires expertise and hands‑on experience in biomedical science. The candidate should have documented expertise in mass spectrometry and chromatography as well as protein and small molecule chemistry. You will support the director through sample preparation, operation/maintenance of advanced mass spectrometers (Orbitrap ID‑X - Vanquish Neo and Orbitrap Astral Zoom - Evosep Eno), and data analysis using advanced software packages (Proteome Discoverer, Compound Discoverer, Scaffold, etc). This work will advance institutional goals in proteomic and metabolomic profiling and translational research.

The ideal candidate will have a proven record of excellent communication and team support. You should be highly motivated and able to work independently when designing and executing experiments. The customer support of researchers within the institution is a high priority. Projects will include use of existing techniques to answer current biological challenges and the development of new technologies in proteomics and metabolomics.

QUALIFICATIONS

• Doctoral degree, preferably a Ph.D. in Mass Spectrometry or in a very closely related field.
• Possess prior experience in qualitative and quantitative proteomics and metabolomics technology and nano‑liquid chromatography and mass spectrometry (LC‑MS; on Orbitrap Fusion, Orbitrap Astral, and/or Orbitrap ID‑X).
• The candidate should be familiar with the entire metabolomics and/or proteomics pipeline (including sample preparation, LC and MS operation, and data analysis) and must be able to conduct independent projects.
• Manage multiple projects between multiple laboratories.
• Demonstrate scientific productivity and have excellent oral and written communication skills.
• Demonstrate attention to detail and ability to learn new technologies, flexibility and time management skills.
• 5+ years' direct experience in mass spectrometry or a MS in very closely related field and 10+ years' experience in proteomics or metabolomics.
• Ability to collaborate across multiple disciplines and engage investigators in project design, execution and data analysis.
• Experience in publication and grant writing.
• Experience with Proteome/Compound Discoverer, Scaffold, MS Dial, MetaboAnalyst, etc.
• Advanced knowledge of Thermo mass spectrometers - operation and maintenance.

PHYSICAL DEMANDS

This is primarily a sedentary job involving extensive use of desktop computers. The job does occasionally require traveling some distance to attend meetings, and programs

Salary will be commensurate with education and experience. This is an exempt‑level, benefited position.

Initial appointments and reappointments to these positions may be made in increments of one to three years, contingent upon satisfactory performance and the availability of funding.

This position is based in Charlottesville, VA, and must be performed fully on‑site.

Background Check

Background checks and pre‑employment health screenings will be conducted on all new hires prior to employment.

Equal Opportunity Statement

The University of Virginia is an equal opportunity employer. All interested persons are encouraged to apply, including veterans and individuals with disabilities. Learn more about UVA's commitment to non‑discrimination and equal opportunity employment.