Senior Scientist, Translational Bioinformatics & mRNA Therapeutics

BioSpace; Cambridge (MA); On-site; USD 146,000 - 234,000; Full time

Benefits offered by this job

Competitive healthcare

Voluntary benefit programs

Well-being resources

Generous paid time off

Location-specific perks

Job summary

Moderna is seeking a Senior Scientist to lead computational efforts in translational bioinformatics for mRNA therapeutics and vaccines. You will apply advanced analytics to bulk and single-cell data, TCR/BCR repertoires, and multi-omics to uncover targets, mechanisms, and biomarkers.

The role emphasizes collaboration across R&D teams, data sharing with external collaborators, and translating insights into actionable recommendations for program decisions and study designs.

Qualifications

• PhD in computational immunology, bioinformatics, biomedical engineering, or a related quantitative discipline with at least 2 years of postdoctoral or industry experience.
• Strong foundation in computational biology and immunology, connecting molecular findings to immune mechanisms and therapeutic development.
• Experience applying computational analyses to human, preclinical and in vitro datasets to support therapeutic development and translational decision-making.
• Experience with immune-mediated diseases, oncology, infectious diseases, immunotherapy, or mRNA therapeutics or vaccines.
• Strong programming in R and/or Python, with Linux environments and data-science workflows.

Responsibilities

• Lead the computational effort for therapeutic and translational programs from discovery through early clinical development.
• Lead integrated multi-omics analyses of data from human clinical and translational studies, preclinical models, and in vitro experiments.
• Perform rigorous bulk and single-cell transcriptomic analyses including QC, cell-type annotation, differential expression, and cross-study integration.
• Analyze TCR/BCR repertoire data including clonotype diversity and associations with phenotypes.
• Develop or apply ML/AI approaches to identify biomarkers, patient stratification, and therapeutic targets.

Skills

Computational biology

Immunology

Machine learning / AI

Advanced statistical methods

Bulk and single-cell transcriptomics

TCR/BCR repertoire analysis

R and Python programming

Leadership / mentorship

Education

PhD in Computational Immunology, Bioinformatics, Biomedical Engineering, or related quantitative discipline

Tools

AWS

GitHub / GitLab

Jupyter

Nextflow

Docker

Linux

Job description

Moderna is seeking a Senior Scientist to lead computational efforts in translational bioinformatics for mRNA therapeutics and vaccines. You will apply advanced analytics to bulk and single-cell data, TCR/BCR repertoires, and multi-omics to uncover targets, mechanisms, and biomarkers.

The role emphasizes collaboration across R&D teams, data sharing with external collaborators, and translating insights into actionable recommendations for program decisions and study designs.