Senior Scientist Structural Biology (X-ray crystallography, Cryo EM)

Hispanic Alliance for Career Enhancement; Boston (MA); Hybrid; USD 80,000 - 110,000; Full time

Job summary

Join a forward-thinking company that is at the forefront of pharmaceutical innovation. We are seeking a creative structural biologist to contribute to groundbreaking research in protein and structural chemistry. This role offers the opportunity to work with a diverse team of experts, utilizing state-of-the-art techniques in X-ray crystallography and Cryo-EM. You will play a pivotal role in driving drug design and development while fostering an inclusive environment that values diverse perspectives. If you are passionate about scientific discovery and collaboration, this position is an exciting opportunity to make a significant impact.

Qualifications

• Ph.D. in structural biology or related field required.
• Experience in X-ray crystallography and Cryo-EM preferred.
• Excellent communication and organizational skills essential.

Responsibilities

• Manage experimental workflow from sample preparation to structure determination.
• Collaborate with cross-functional teams and external scientific community.
• Present findings at external meetings and manage scientific partnerships.

Skills

X-ray crystallography

Cryo-EM

Communication Skills

Organizational Abilities

Research Publication

Education

Ph.D. in Structural Biology

Ph.D. in Biochemistry

Tools

Computational Tools for Protein Engineering

Scientific Programming (Python)

Job description

Job Description

Are you ready to embark on an exhilarating career journey that combines innovation, collaboration, and impactful scientific discovery? At our Company, a global leader in pharmaceuticals, renowned for our commitment to excellence and groundbreaking research, we are committed to improving lives through innovative medicines, vaccines, and animal health products.

Protein and Structural Chemistry (PSC), a global team in Discovery Chemistry (DC), supports protein structural determination from Discovery to Development, agnostic to the modalities (small molecule, peptide, and macromolecules). Furthermore, we elucidate the structural basis of mechanisms of action and perform analyses to develop formulations. PSC is a diverse and inclusive team of approximately 40 structural biologists that collaborate closely with medicinal and computational chemists, informaticians, mass spectrometrists, biophysicists, protein scientists, and pharmacologists who employ state-of-the-art capabilities to drive drug design and development.

We are seeking a creative, self-motivated structural biologist with exceptional interpersonal and problem-solving skills to join our growing PSC group in the DC department at our Boston, Massachusetts site. The successful candidate must have experience in X-ray crystallography and/or Cryo-EM and will be responsible for all aspects of the experimental workflow from sample preparation and data collection through data processing, structure determination, and the effective communication of structural analyses with key stakeholders. Additionally, the candidate will work proactively with colleagues in Modeling & Informatics, Discovery Chemistry, Screening and Compound Profiling, and Mass Spectrometry and Biophysics, and will also be expected to identify and manage internal and external scientific partnerships as necessary.

Productive and collaborative interactions with other members of our global, cross-functional department are required in this role. Inclusive and collaborative use of internal expertise and resources will be essential to success. The successful candidate is expected to foster and contribute to a diverse workforce where colleagues and partners feel comfortable bringing their unique perspectives to work.

The position requires active interaction with the external scientific community to continually improve scientific understanding, including presentations at external meetings.

There is an expectation for periodic travel to other locations.

Required Experience and Skills:

• Ph.D. in structural biology, biochemistry, or related field.

• Experience in a broad range of activities for X-ray crystallography, including crystallization screening and optimization, crystal harvesting, data collection and structure determination, and/or proficiency in atomic resolution single particle CryoEM, including sample preparation, data collection, image processing, and structure determination.

• Excellent written and verbal communication skills to facilitate team progress and ensure clarity on program status for therapeutic team and management is required.

• Demonstrated strong organizational abilities with a proven track record of managing timeline effectively.

• Ability to prepare and publish peer-reviewed research.

Preferred Experience and Skills:

• Experience with structure determination of small molecule-protein complexes and multi-subunit protein complexes.

• Knowledge of current biophysical and functional characterization methods (e.g. SPR, thermal shift, ligand-binding, and calorimetric assays) to inform construct design and optimization.

• Experience using computational tools for protein engineering and design.

• Experience with scientific programming (e.g. Python) and interest in the application of computational tools to answer structural biology questions.

Current Employees apply HERE

Current Contingent Workers apply HERE

US and Puerto Rico Residents Only:

Our company is committed to inclusion, ensuring that candidates can engage in a hiring process that exhibits their true capabilities. Please click here if you need an accommodation during the application or hiring process.

As an Equal Employment Opportunity Employer, we provide equal opportunities to all employees and applicants for employment and prohibit discrimination on the basis of race, color, age, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, disability status, or other applicable legally protected characteristics. As a federal contractor, we comply with all affirmative action requirements for protected veterans and individuals with disabilities. For more information about personal rights under the U.S. Equal Opportunity Employment laws, visit:

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We are proud to be a company that embraces the value of bringing together, talented, and committed people with diverse experiences, perspectives, skills and backgrounds. The fastest way to breakthrough innovation is when people with diverse ideas, broad experiences, backgrounds, and skills come together in an inclusive environment. We encourage our colleagues to respectfully challenge one another's thinking and approach problems collectively.

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U.S. Hybrid Work Model

Effective September 5, 2023, employees in office-based positions in the U.S. will be working a Hybrid work consisting of three total days on-site per week, Monday - Thursday, although the specific days may vary by site or organization, with Friday designated as a remote-working day, unless business critical tasks require an on-site presence.This Hybrid work model does not apply to, and daily in-person attendance is required for, field-based positions; facility-based, manufacturing-based, or research-based positions where the work to be performed is located at a Company site; positions covered by a collective-bargaining agreement (unless the agreement provides for hybrid work); or any other position for which the Company has determined the job requirements cannot be reasonably met working remotely. Please note, this Hybrid work model guidance also does not apply to roles that have been designated as "remote".

San Francisco Residents Only: We will consider qualified applicants with arrest and conviction records for employment in compliance with the San Francisco Fair Chance Ordinance

Los Angeles Residents Only: We will consider for employment all qualified applicants, including those with criminal histories, in a manner consistent with the requirements of applicable state and local laws, including the City of Los Angeles' Fair Chance Initiative for Hiring Ordinance

Search Firm Representatives Please Read Carefully
Merck & Co., Inc., Rahway, NJ, USA, also known as Merck Sharp & Dohme LLC, Rahway, NJ, USA, does not accept unsolicited assistance from search firms for employment opportunities. All CVs / resumes submitted by search firms to any employee at our company without a valid written search agreement in place for this position will be deemed the sole property of our company. No fee will be paid in the event a candidate is hired by our company as a result of an agency referral where no pre-existing agreement is in place. Where agency agreements are in place, introductions are position specific. Please, no phone calls or emails.

Employee Status:
Regular

Relocation:
Domestic/International

VISA Sponsorship:
Yes

Travel Requirements:
10%

Flexible Work Arrangements:
Not Applicable

Shift:
Not Indicated

Valid Driving License:
No

Hazardous Material(s):
N/A

Job Posting End Date:
05/13/2025
*A job posting is effective until 11:59:59PM on the day BEFORE the listed job posting end date. Please ensure you apply to a job posting no later than the day BEFORE the job posting end date.

Requisition ID:R346795