Principal Scientist, Structural Biology

HotSpot Therapeutics, Inc; Massachusetts; Hybrid; USD 90,000 - 150,000; Full time

Job summary

An established industry player is seeking a passionate structural biologist to lead innovative drug discovery programs. This full-time, hybrid role in Boston offers an exciting opportunity to influence the future of drug development through cutting-edge techniques like X-ray crystallography and Cryo-EM. The ideal candidate will possess a Ph.D. and extensive experience in structural biology, showcasing a strong publication record. Join a dynamic team that values collaboration and creativity, and contribute to groundbreaking advancements in the field. If you are ready to make a significant impact in a supportive environment, this role is perfect for you.

Benefits

Competitive salary and bonus plans

Comprehensive benefits package

Generous paid holidays

Supportive team environment

Ownership in the company

Qualifications

• Ph.D. with 8+ years of experience in structural biology.
• Extensive experience in solving protein structures using X-ray crystallography, cryo-EM, and NMR.
• Strong publication record in structure-enabled drug discovery.

Responsibilities

• Lead scientific and operational aspects of structural biology for drug discovery.
• Oversee protein sciences team and manage external resources.
• Design strategies for protein engineering and structural biology.

Skills

X-ray crystallography

Cryo-EM

NMR

Analytical techniques (SEC-MALS, DLS, DSF)

Biochemical/biophysical assay methods

Project management

Interpersonal skills

Problem-solving skills

Education

Ph.D. in structural biology or related discipline

Tools

TR-FRET

AlphaLISA

FP

MST

MSD

Job description

Full-time, hybrid role based in Boston, MA

At HotSpot, we’re not just looking for the brightest minds or for the most brilliant individual contributors. We want passionate team members who are comfortable adjusting their lens, aren’t afraid to think big, test bold ideas, and celebrate collective wins. We have established core values that resemble who we are and define our company culture. We are building a company where values drive everything we do inside and outside the organization.

#Courageous Adventurers #Leave your Mark #Keep it Human #Make it Real

RESPONSIBILITIES:

• Lead the scientific, technical, and operational aspects of structural biology for drug discovery programs
• Lead a multitude of efforts in parallel including X-ray crystallography, Cryo-EM, and NMR, each with a clear goal of delivering novel and iterative protein structure with small molecules to enable structure-based drug design and insight on MOA.
• Oversee a world class protein sciences team, supervising the design of protein constructs and protein production to support assay development and structural biology.
• Design structural biology strategies, such as protein engineering using rational design, fusion proteins, loop deletions, surface entropy reduction, mutagenesis, etc.
• Effectively interact with colleagues in biochemistry and biophysics, computational chemistry, medicinal chemistry, cell biology, and other functional groups to drive project progression.
• Manage external resources to ensure delivery of high-quality protein structural information, efficient recombinant protein design, protein expression, protein purification, crystallization, data collection and refinement.
• Devise and implement experiments to develop robust protocols to generate iterative co-complex structures, perform structural refinement with in-depth understanding of drug-protein interactions and articulate clearly detailed findings to the team.
• Demonstrated track record of accomplishments through use of strong problem-solving skills, as evidenced from strong peer-reviewed publication record
• Lead structure biology aspect of publication and poster presentations

QUALIFICATIONS:

• Ph.D. in structural biology or a related discipline with a demonstrated level of expertise, or equivalent. A minimum of 8+ years of relevant experience, including industry or a combination of post-doc and industry experience, is preferred.
• Extensive experience in solving protein structures using X-ray crystallography, cryo-EM and NMR; experience with small molecule allosteric inhibitors is a plus.
• Proven ability to design and troubleshoot protein constructs for crystallization, solve structures for technically challenging proteins, and elucidating co-structures of small molecules with target proteins.
• Demonstrated track record of success in structure-enabled drug discovery programs, as evidenced by a significant publication record in journals, patents and presentations
• Experience in using analytical/biophysical techniques (SEC-MALS, DLS, DSF, etc.) for assessing stability, solubility, and oligomerization status of proteins.
• Experience and willingness to occasionally perform biochemical/biophysical assay methods such as TR-FRET, AlphaLISA, FP, MST, MSD, etc., is a plus.
• Experience in managing CROs to solve problems and drive progress of the projects
• Exceptional interpersonal and communication skills, and the ability to work seamlessly with multiple drug discovery teams and provide structure related support at all stages of the project
• Strong organizational skills, ability to manage multiple projects simultaneously, and the capability to prioritize and focus on delivery of data for key decision making
• Efficient and comfortable with working remotely with teams at different locations
• Ability and willingness to learn and adopt emerging technologies to drug discovery process

OUR BENEFITS:

We believe that people are our greatest resource and foster a supportive environment that provides growth and development for all teammates. We recognize and reward performance and incentivizes long-term success. From benefits that focus on your health and well-being to competitive compensation to ownership in the company, we want to inspire our employees.

Our Benefits Include, But Are Not Limited To:

• Competitive salary and bonus plans
• Comprehensive package of benefits plans and fringe benefits
• Generous paid holidays, time off, including 2 company wide shutdowns
• Amazing team of supportive colleagues

At HotSpot, we have a bold mission to establish new drug discovery paradigm. If this appeals to you, please let us know at [e-mail] .

HotSpot is an equal opportunity employer. We celebrate diversity and are committed to creating an inclusive environment for all employees.

At this time, HotSpot is not able to offer Visa sponsorship for this position. Candidates must be authorized to work in the United States without current or future sponsorship.

HotSpot requires its employees to be fully vaccinated against COVID-19, as defined by the CDC. Additionally, HotSpot employees are required to comply with state, local, and vendor COVID-19 vaccination requirements.