Senior Scientist, Structural Biology

Scorpion Therapeutics; Spring House (PA); On-site; USD 120,000 - 180,000; Full time

Job summary

Scorpion Therapeutics in Spring House, PA is seeking a Senior Scientist in Structural Biology to accelerate therapeutic discovery through high-impact structural studies, focusing on antibody-antigen complexes and cryo-EM.

You will purify and characterize antibodies and antigens, prepare cryo-EM samples, analyze data, and collaborate with biologics, protein sciences, and biophysics teams to inform design and optimization.

Qualifications

• PhD in Structural Biology, Biochemistry, or Biophysics with 2+ years postdoctoral or industry experience.
• expertise in antibody-antigen structural biology, cryo-EM, protein expression, purification, and complex assembly
• proficiency with cryo-EM software and structural analysis tools
• strong collaboration, communication, and problem-solving skills.

Responsibilities

• Purifying and characterizing antibodies, antigens, and complexes.
• Preparing cryo-EM samples, processing data, and interpreting structures to inform antibody design and optimization.
• Utilizing complementary techniques like crystallography and biophysical methods.
• Maintaining detailed records, troubleshooting workflows, and collaborating with cross-functional teams in biologics, protein sciences, and biophysics.

Skills

Antibody-antigen structural biology

cryo-EM

protein expression

purification

biophysics

crystallography

data processing

communication

collaboration

Education

PhD in Structural Biology, Biochemistry, or Biophysics

Tools

cryo-EM software

Job description

Role

Senior Scientist in Structural Biology focused on accelerating therapeutic discovery through high-impact structural studies.

Responsibilities

• Responsibilities include purifying and characterizing antibodies, antigens, and complexes
• preparing cryo-EM samples, processing data, and interpreting structures to inform antibody design and optimization
• utilizing complementary techniques like crystallography and biophysical methods
• maintaining detailed records, troubleshooting workflows, and collaborating with cross-functional teams in biologics, protein sciences, and biophysics.

Qualifications

• PhD in Structural Biology, Biochemistry, or Biophysics with 2+ years postdoctoral or industry experience
• expertise in antibody-antigen structural biology, cryo-EM, protein expression, purification, and complex assembly
• proficiency with cryo-EM software and structural analysis tools
• strong collaboration, communication, and problem-solving skills.

Preferred

• experience with negative-stain EM, crystallography, antibody discovery, and structure-guided design
• evidenced impact on drug discovery projects through published structures.

HighValue

focus on biologics, antibody complexes, cryo-EM, structure-based drug design, and collaborative cross-disciplinary research.

WorkSetup

located in Spring House, PA; specific travel requirements not detailed.