Senior Scientist - siRNA Therapeutics & Discovery

Qilu Pharmaceuticals; Boston (MA); On-site; USD 120,000 - 180,000; Full time

Job summary

Qilu Pharmaceuticals seeks highly motivated scientists to join our RNA Therapy team. The role focuses on siRNA therapeutic discovery, combining in vitro and in vivo approaches to advance preclinical candidates for metabolic, liver, neurological, and ocular diseases.

You will develop and optimize cellular and biochemical assays, collaborate with cross-functional teams, and present findings to leadership. PhD with 3+ years biotech experience required.

Qualifications

• Ph.D. in Molecular Biology, Pharmacology, Neuroscience, or a related discipline, with 3+ years of industry experience in biotechnology or pharmaceutical research; or 5+ years of relevant postdoctoral experience.
• Experience working with siRNA, ASO, or other oligonucleotide therapeutics.
• Extensive hands-on experience with RT-qPCR, ELISA, Western blotting, mammalian cell culture, animal handling, tissue collection, and tissue processing is required.
• Preferred technical skills include primary neuronal cell culture, stem-loop qPCR, and rodent dosing techniques, including tail vein injection and intracranial administration.

Responsibilities

• Lead and execute preclinical screening and evaluation of siRNA candidates to support lead identification and candidate selection through integrated in vitro and in vivo studies.
• Investigate target biology and mechanism of action; design and conduct proof-of-concept studies to validate therapeutic targets in collaboration with internal teams and external partner.
• Develop, optimize, and implement cellular and biochemical assays to support drug discovery and preclinical research activities.
• Collaborate closely with cross-functional teams, including chemistry, non-clinical development, bioinformatics, and external CRO partner.
• Manage multiple projects and priorities simultaneously while delivering high-quality results within established timeline.
• Demonstrate scientific creativity, critical thinking, and a strong commitment to innovation.
• Maintain compliance with applicable SOPs and laboratory standards; provide technical guidance and training to junior team members as needed.
• Present scientific findings to project teams, leadership committees, and external collaborators. Communicate effectively across functions and organizational level

Skills

RT-qPCR

ELISA

Western blotting

Mammalian cell culture

Animal handling

Tissue processing

Stem-loop qPCR

Rodent dosing techniques

Presentation skills

Scientific writing

Education

Ph.D. in Molecular Biology, Pharmacology, Neuroscience, or related

Job description

Qilu Pharmaceuticals seeks highly motivated scientists to join our RNA Therapy team. The role focuses on siRNA therapeutic discovery, combining in vitro and in vivo approaches to advance preclinical candidates for metabolic, liver, neurological, and ocular diseases.

You will develop and optimize cellular and biochemical assays, collaborate with cross-functional teams, and present findings to leadership. PhD with 3+ years biotech experience required.