Senior Scientist, siRNA Design & Off-Target Analytics

Biopharma Careers; Maryland; On-site; USD 120,000 - 180,000; Full time

Job summary

AbbVie in Maryland is seeking a Senior Scientist in the Biotherapeutic and Genetic Medicine (BGM) group to advance siRNA design and off-target assessment. You will establish pipelines integrating genomic and transcriptomic data, and build ML models to improve knockdown specificity.

Collaborating with in vitro and AI teams, you will develop reusable tools in Python/R, generate clear data reports, and contribute to safer RNA-based therapeutics.

Qualifications

• PhD/MS/BS in computational biology or related field with biotech industry experience.
• Proficiency in Python and/or R and reproducible analytical workflows.
• Experience supporting off-target analysis for siRNA or related modalities.
• Strong background in NGS data analysis and transcriptomics.

Responsibilities

• Establish, implement, and improve pipelines for siRNA sequence design with genomic data.
• Build ML models using high-throughput siRNA screening data.
• Collaborate on NGS library preparation for off-target analysis.
• Interpret transcriptomic data to identify off-target signals and risks.
• Develop reusable tools and pipelines in Python, R, or other languages.
• Generate clear data analysis reports and technical summaries.
• Collaborate with assay scientists and cross-functional partners to translate findings.

Skills

Python

R

NGS data analysis

Bioinformatics

Education

PhD in computational biology

Tools

Python

R

Job description

AbbVie in Maryland is seeking a Senior Scientist in the Biotherapeutic and Genetic Medicine (BGM) group to advance siRNA design and off-target assessment. You will establish pipelines integrating genomic and transcriptomic data, and build ML models to improve knockdown specificity.

Collaborating with in vitro and AI teams, you will develop reusable tools in Python/R, generate clear data reports, and contribute to safer RNA-based therapeutics.