Senior Scientist - siRNA Bioanalysis & Mechanistic Studies

Initial Therapeutics, Inc.; South San Francisco (CA); On-site; USD 130,000 - 160,000; Full time

Benefits offered by this job

Health insurance

Retirement and Savings Plan

Flexible work models

Stock-based long-term incentives

Award-winning time-off plans

Job summary

Initial Therapeutics, Inc. in South San Francisco is seeking a Senior Scientist specializing in siRNA Bioanalysis & Mechanistic Studies. The successful candidate will engage in bioanalytical research to advance siRNA therapeutics and will require expertise in ADME, pharmacokinetics, and mechanism-driven assays.

We offer a competitive salary as well as a comprehensive benefits package, including health coverage, retirement plans, and work-life balance opportunities. Join us to impact patient lives positively.

Qualifications

• Doctorate in pharmacology, biochemistry, or related field.
• Experience in bioanalysis of siRNA therapeutics.
• Knowledge of pharmacokinetics and mechanistic assays.

Responsibilities

• Conduct bioanalysis of siRNA therapeutics in preclinical samples.
• Establish innovative in vitro ADME assays for characterizing siRNA.
• Design and execute in vivo studies for pharmacokinetics insights.

Skills

siRNA therapeutics

ADME knowledge

critical thinking

problem-solving

data interpretation

communication skills

Education

Doctorate degree in pharmacology or related discipline

Masters degree in pharmacology or related discipline with 3 years industry experience

Bachelors degree in pharmacology or related discipline with 6 years industry experience

Tools

LC/MS bioanalytical platforms

ligand binding assays

nucleic acid quantification techniques

Job description

Join Amgen's mission of serving patients. At Amgen, if you feel like you’re part of something bigger, it’s because you are. Our shared mission to serve patients living with serious illnesses drives all that we do.

Since 1980, we’ve helped pioneer the world of biotech in our fight against the world’s toughest diseases. With our focus on four therapeutic areas – Oncology, Inflammation, General Medicine, and Rare Disease – we reach millions of patients each year. As a member of the Amgen team, you’ll help make a lasting impact on the lives of patients as we research, manufacture, and deliver innovative medicines to help people live longer, fuller, happier lives.

Our award‑winning culture is collaborative, innovative, and science‑based. If you have a passion for challenges and the opportunities that lie within them, you’ll thrive as part of the Amgen team. Join us and transform the lives of patients while transforming your career.

Senior Scientist – siRNA Bioanalysis & Mechanistic Studies

What you will do

In this vital role you will add to our diverse team in Pharmacokinetics & Drug Metabolism Bioanalytical Sciences (PKDM‑BA) to advance our growing siRNA research portfolio. You will contribute to the execution of innovative bioanalytical platforms to measure siRNA in preclinical samples, both in vitro and in vivo, for characterizing ADME and elucidating pharmacokinetics and pharmacokinetic‑pharmacodynamic relationships. You will also work independently and in teams to design and perform mechanistic studies for siRNA discovery research programs to support clinical candidate selection and regulatory applications.

• Independently and collaboratively conduct bioanalysis of siRNA therapeutics in preclinical samples (in vitro and in vivo)
• Work independently and in teams to establish innovative in vitro ADME assays for characterizing siRNA mechanism of action and generate high‑quality, mechanistic insights to support discovery programs
• Work independently and in teams to design, execute, and interpret results from in vivo studies characterizing pharmacokinetics, pharmacokinetic‑pharmacodynamic relationships, tissue distribution, and toxicokinetics of siRNA therapeutics
• Build strong interdepartmental relationships and foster cross‑functional collaboration across Research and Development to advance siRNA therapeutics from discovery to clinical proof of concept

What we expect of you

We are all different, yet we all use our unique contributions to serve patients. The dynamic professional we seek is a leader with these qualifications.

Basic Qualifications

• Doctorate degree [and relevant post‑doc where applicable] in pharmacology, biochemistry or a related scientific discipline
• Masters degree in pharmacology, biochemistry or a related scientific discipline and 3 years of industry experience
• Bachelors degree in pharmacology, biochemistry or a related scientific discipline and 6 years of industry experience

Preferred Qualifications

• Extensive knowledge of siRNA therapeutics, particularly within the context of ADME and pharmacokinetics
• Proven experience in designing and executing fit‑for‑purpose mechanistic assays to address key scientific questions related to siRNA therapeutics
• Hands‑on experience with ligand binding assays (specifically immunoassay and hybridization assays), LC/MS bioanalytical platforms, and nucleic acid quantification techniques (RT‑qPCR or RT‑ddPCR)
• Strong critical thinking, problem‑solving, and data interpretation skills
• Excellent written and verbal communication skills

What you can expect of us

As we work to develop treatments that take care of others, we also care for your professional and personal growth and well­being. From our competitive benefits to our collaborative culture, we support your journey every step of the way.

The expected annual salary range for this role in the U.S. (excluding Puerto Rico) is posted. Actual salary will vary based on several factors including but not limited to, relevant skills, experience, and qualifications.

In addition to the base salary, Amgen offers a Total Rewards Plan, based on eligibility, comprising of health and welfare plans for staff and eligible dependents, financial plans with opportunities to save towards retirement or other goals, work/life balance, and career development opportunities that may include:

• A comprehensive employee benefits package, including a Retirement and Savings Plan with generous company contributions, group medical, dental and vision coverage, life and disability insurance, and flexible spending accounts
• A discretionary annual bonus program, or for field sales representatives, a sales‑based incentive plan
• Stock‑based long‑term incentives
• Award‑winning time‑off plans
• Flexible work models where possible. Refer to the Work Location Type in the job posting to see if this applies.

Apply now and make a lasting impact with the Amgen team.

careers.amgen.com

Application Deadline

Amgen does not have an application deadline for this position; we will continue accepting applications until we receive a sufficient number or select a candidate for the position.

Sponsorship

Sponsorship for this role is not guaranteed.

As an organization dedicated to improving the quality of life for people around the world, Amgen fosters an inclusive environment of diverse, ethical, committed and highly accomplished people who respect each other and live the Amgen values to continue advancing science to serve patients. Together, we compete in the fight against serious disease.

Amgen is an Equal Opportunity employer and will consider all qualified applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, disability status, or any other basis protected by applicable law.

We will ensure that individuals with disabilities are provided reasonable accommodation to participate in the job application or interview process, to perform essential job functions, and to receive other benefits and privileges of employment. Please contact us to request accommodation.

In any materials you submit, you may redact or remove age‑identifying information such as age, date of birth, or dates of school attendance or graduation. You will not be penalized for redacting or removing this information.